靶向急性心肌梗死后肠道免疫心脏调节心脏重构

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-04-04 DOI:10.1016/j.lfs.2025.123606

Jinmei Yu, Lin Zhou, Guo Li, Zaiyi Chen, Muhammad Saqib Mudabbar, Le Li, Xinyi Tang, Mimi Jiang, Guolan Zhang, Xing Liu

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引用次数: 0

摘要

肠道菌群与宿主相互作用，调节疾病和健康状态。越来越多的研究认识到肠道微生物群与免疫细胞之间的双向调节，在疾病的病因和预后中起着重要作用。肠道微生物群也是心血管疾病的关键调节因素。急性心肌梗死后，心肌和内皮损伤迅速引发炎症反应，激活免疫系统，破坏肠道菌群生态，从而影响急性心肌梗死后心脏重构，可能导致心力衰竭。我们已经阐明了在急性心肌梗死后心脏重构过程中免疫系统中复杂的细胞间网络的调控机制。此外，本研究还探讨了肠道微生物群、免疫细胞和肠道代谢物在心肌梗死后心脏重塑和心力衰竭中的作用和机制。最后，我们讨论了通过饮食调节、益生菌补充和微生物群移植等方法，靶向肠道免疫细胞作为未来预防和治疗急性心肌梗死后心力衰竭的有效途径的潜力。

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Targeting gut-immune-heart modulate cardiac remodeling after acute myocardial infarction

The gut microbiota interacts with the host to regulate disease and health status. An increasing number of studies have recognized the bidirectional regulation between gut microbiota and immune cells, which plays a significant role in the etiology and prognosis of diseases. Gut microbiota is also a crucial regulatory factor in cardiovascular diseases. After acute myocardial infarction, myocardial and endothelial damage rapidly triggers an inflammatory response, activating the immune system and disrupting the gut microbiota ecology, thereby affecting cardiac remodeling after acute myocardial infarction and potentially leading to heart failure. We have elucidated the regulatory mechanisms of complex intercellular networks in the immune system during cardiac remodeling after acute myocardial infarction. Furthermore, this research examines the roles and mechanisms of gut microbiota, immune cells, and gut metabolites in relation to cardiac remodeling and heart failure after myocardial infarction. Finally, we discuss the potential of targeting gut immune cells as an effective approach to prevent and treat heart failure after acute myocardial infarction in the future, through methods such as dietary regulation, probiotic supplementation, and microbiota transplantation.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.