分批和流动光化学研究烷基氮杂啶

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-04 DOI:10.1021/acs.orglett.5c00922

Oleksandr P. Datsenko, Andrii Baziievskyi, Iryna Sadkova, Bismarck Campos, James T. Brewster, II, John Kowalski, Ronald J. Hinklin, Pavel K. Mykhailiuk

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引用次数: 0

摘要

通过对氮杂啶-2羧酸进行间歇和流动光化学修饰，制备了烷基氮杂啶。这个反应以毫克、克甚至数克的量来实现。所获得的氮杂苷是药物发现的宝贵基石。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Alkyl Azetidines Via Batch and Flow Photochemistry

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Alkyl Azetidines Via Batch and Flow Photochemistry

Alkyl azetidines have been prepared by photochemical modifications of azetidine-2-carboxylic acids in batch and in flow. The reaction has been realized in milligram, gram, and even multigram quantities. The obtained azetidines are valuable building blocks for drug discovery.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.