Yasmin Ezzatvar, José Francisco López-Gil, Rodrigo Yáñez-Sepúlveda, Jorge Olivares-Arancibia, Jacqueline Páez-Herrera, Antonio García-Hermoso
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Samples were analyzed using single-molecule array (Simoa) technology on a Quanterix HD-1 analyzer, using digital enzyme-linked immunosorbent assay to quantify NfL and tau proteins from serum and plasma samples.</p><p><strong>Results: </strong>In the present study, 3,182 individuals participated, with females comprising 61% of the sample. Participants adhering to the PA guidelines in both waves reported lower levels of NfL (-0.583 pg/mL, 95% bias-corrected and accelerated (BCa) confidence interval (CI): -1.235 to -0.068) and tau protein levels (-0.244 pg/mL, 95% BCa CI: -0.405 to -0.078). Adjusted analyses confirmed significant lower levels of tau protein (-0.210 pg/mL, 95% BCa CI: -0.350 to -0.072) for Wave I adherents and even lower levels in NfL (-0.421 pg/mL, 95% BCa CI: -0.929 to -0.007) and tau protein levels (-0.229 pg/mL, 95% BCa CI: -0.412 to -0.053) for active participants in both waves.</p><p><strong>Discussion: </strong>Our findings suggest that consistent engagement in PA may reduce certain neurodegenerative biomarkers, potentially influencing neurological health outcomes.</p>","PeriodicalId":56278,"journal":{"name":"Journal of Adolescent Health","volume":" ","pages":""},"PeriodicalIF":5.5000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Physical Activity is Related to Lower Levels of Neurofilament Light and Plasma Tau Protein: A 22-Year Follow-Up Study From Adolescence to Adulthood.\",\"authors\":\"Yasmin Ezzatvar, José Francisco López-Gil, Rodrigo Yáñez-Sepúlveda, Jorge Olivares-Arancibia, Jacqueline Páez-Herrera, Antonio García-Hermoso\",\"doi\":\"10.1016/j.jadohealth.2025.02.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate the association between physical activity (PA) and neurodegeneration biomarkers from adolescence to adulthood by examining tau protein and neurofilament light chain (NfL) levels in blood samples.</p><p><strong>Methods: </strong>The study analyzed data from adolescents aged 12-19 years who participated in Waves I (1994-1996) and V (2016-2018) of the Add Health study over a span of 22 years. 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引用次数: 0
摘要
目的：通过检测血液样本中的 tau 蛋白和神经丝轻链（NfL）水平，研究从青春期到成年期体育锻炼（PA）与神经退行性变生物标志物之间的关联：该研究分析了参加 Add Health 研究第一波（1994-1996 年）和第五波（2016-2018 年）的 12-19 岁青少年在 22 年间的数据。该研究通过自我报告问卷对 PA 进行了评估。第五波的神经变性测量使用抽血收集的静脉血。在Quanterix HD-1分析仪上使用单分子阵列（Simoa）技术对样本进行分析，使用数字酶联免疫吸附测定法对血清和血浆样本中的NfL和tau蛋白进行量化：本研究共有 3,182 人参与，其中女性占样本的 61%。在两波研究中均遵守PA指南的参与者报告了较低的NfL水平（-0.583 pg/mL，95%偏差校正和加速（BCa）置信区间（CI）：-1.235至-0.068）和tau蛋白水平（-0.244 pg/mL，95% BCa CI：-0.405至-0.078）。调整分析证实，第一波参与者的 tau 蛋白水平显著降低（-0.210 pg/mL，95% BCa CI：-0.350 至 -0.072），而两波的积极参与者的 NfL 水平（-0.421 pg/mL，95% BCa CI：-0.929 至 -0.007）和 tau 蛋白水平（-0.229 pg/mL，95% BCa CI：-0.412 至 -0.053）甚至更低：我们的研究结果表明，坚持参加体育锻炼可降低某些神经退行性疾病的生物标志物，从而对神经系统的健康状况产生潜在影响。
Physical Activity is Related to Lower Levels of Neurofilament Light and Plasma Tau Protein: A 22-Year Follow-Up Study From Adolescence to Adulthood.
Purpose: To investigate the association between physical activity (PA) and neurodegeneration biomarkers from adolescence to adulthood by examining tau protein and neurofilament light chain (NfL) levels in blood samples.
Methods: The study analyzed data from adolescents aged 12-19 years who participated in Waves I (1994-1996) and V (2016-2018) of the Add Health study over a span of 22 years. It assessed PA through self-reported questionnaires. Neurodegeneration measures at Wave V used venous blood collected via phlebotomy. Samples were analyzed using single-molecule array (Simoa) technology on a Quanterix HD-1 analyzer, using digital enzyme-linked immunosorbent assay to quantify NfL and tau proteins from serum and plasma samples.
Results: In the present study, 3,182 individuals participated, with females comprising 61% of the sample. Participants adhering to the PA guidelines in both waves reported lower levels of NfL (-0.583 pg/mL, 95% bias-corrected and accelerated (BCa) confidence interval (CI): -1.235 to -0.068) and tau protein levels (-0.244 pg/mL, 95% BCa CI: -0.405 to -0.078). Adjusted analyses confirmed significant lower levels of tau protein (-0.210 pg/mL, 95% BCa CI: -0.350 to -0.072) for Wave I adherents and even lower levels in NfL (-0.421 pg/mL, 95% BCa CI: -0.929 to -0.007) and tau protein levels (-0.229 pg/mL, 95% BCa CI: -0.412 to -0.053) for active participants in both waves.
Discussion: Our findings suggest that consistent engagement in PA may reduce certain neurodegenerative biomarkers, potentially influencing neurological health outcomes.
期刊介绍：
The Journal of Adolescent Health is a scientific publication dedicated to enhancing the health and well-being of adolescents and young adults. Our Journal covers a broad range of research topics, spanning from the basic biological and behavioral sciences to public health and policy. We welcome a variety of contributions, including original research papers, concise reports, literature reviews, clinical case reports, opinion pieces, and letters to the editor. We encourage professionals from diverse disciplines such as Anthropology, Education, Ethics, Global Health, Health Services Research, Law, Medicine, Mental and Behavioral Health, Nursing, Nutrition, Psychology, Public Health and Policy, Social Work, Sociology, and Youth Development to share their expertise and contribute to our mission of promoting adolescent health. Moreover, we value the voices of young individuals, family and community members, and healthcare professionals, and encourage them to submit poetry, personal narratives, images, and other creative works that provide unique insights into the experiences of adolescents and young adults. By combining scientific peer-reviewed research with creative expressions, our Journal aims to create a comprehensive understanding of the challenges and opportunities in adolescent and young adult health.
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