Ruoyu Chen, Sherilyn Grill, Benjamin Lin, Mariyah Saiduddin, Ruth Lehmann
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引用次数: 0
摘要
物种的延续取决于生殖细胞。生殖细胞不同于身体的其他细胞类型（体细胞），因为它们只发育成配子（精子或卵子），以创造下一代。在本综述中，我们将探讨黑腹果蝇胚胎生殖细胞发育的四个方面：种质的组装和功能，种质中含有决定生殖细胞规格和命运的因子以及下一代的线粒体；极体细胞的形成过程，极体细胞将产生原始生殖细胞（PGC）；极体细胞向 PGC 命运的规格化；最后，PGC 迁移到体细胞性腺前体，与体细胞性腺前体一起形成胚胎睾丸和卵巢。
Origin and establishment of the germline in Drosophila melanogaster.
The continuity of a species depends on germ cells. Germ cells are different from all the other cell types of the body (somatic cells) as they are solely destined to develop into gametes (sperm or egg) to create the next generation. In this review, we will touch on 4 areas of embryonic germ cell development in Drosophila melanogaster: the assembly and function of germplasm, which houses the determinants for germ cell specification and fate and the mitochondria of the next generation; the process of pole cell formation, which will give rise to primordial germ cells (PGCs); the specification of pole cells toward the PGC fate; and finally, the migration of PGCs to the somatic gonadal precursors, where they, together with somatic gonadal precursors, form the embryonic testis and ovary.
期刊介绍：
GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work.
While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal.
The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists.
GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.
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