将无微生物细胞DNA检测纳入医疗保健相关的侵袭性真菌感染监测：益处和挑战

IF 3 4区医学 Q2 INFECTIOUS DISEASES

Infection Control and Hospital Epidemiology Pub Date : 2025-04-04 DOI:10.1017/ice.2025.48

Daniel Z Uslan, Ishminder Kaur, Omai B Garner, Shangxin Yang

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引用次数: 0

摘要

临床流行病学团队对医疗机构侵袭性真菌感染（IFIs）的监测可能具有挑战性，原因包括非侵入性传统微生物学诊断的低敏感性、非特异性临床表现和复杂的患者群体。最近，通过Karius Test获得的无微生物细胞DNA检测（cfDNA）有望提高ifi的诊断敏感性。然而，如何最好地将cfDNA结果纳入IFI监测仍然是一个棘手的挑战。在此，我们提供了使用cfDNA进行IFI监测的好处和挑战的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Incorporating microbial cell-free DNA testing into healthcare-associated invasive fungal infection surveillance: benefits and challenges.

Surveillance by clinical epidemiology teams for invasive fungal infections (IFIs) in healthcare settings can be challenging due to several factors including low sensitivity of noninvasive conventional microbiologic diagnostics, nonspecific clinical presentation, and complex patient populations. Recently, availability of microbial cell-free DNA testing (cfDNA) via the Karius Test has shown promise for increased diagnostic sensitivity of IFIs. However, how to best incorporate cfDNA results into IFI surveillance remains a vexing challenge. Herein, we provide perspectives on the benefits and challenges of use of cfDNA for IFI surveillance.

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来源期刊

Infection Control and Hospital Epidemiology 医学-传染病学

CiteScore

6.40

自引率

6.70%

发文量

289

审稿时长

3-8 weeks

期刊介绍： Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. Written by infection control practitioners and epidemiologists and guided by an editorial board composed of the nation''s leaders in the field, ICHE provides a critical forum for this vital information.