多囊卵巢综合征、子宫内膜异位症与静脉血栓栓塞症：一项基于人群的研究。

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Gynecologic and Obstetric Investigation Pub Date : 2025-04-03 DOI:10.1159/000545518

Hormoz Nassiri Kigloo, Vicky Mai, Eva Suarthana, Togas Tulandi, Steeve Provencher

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引用次数: 0

摘要

背景：目前关于多囊卵巢综合征（PCOS）和子宫内膜异位症与静脉血栓栓塞（VTE）发生之间关系的研究较少。目的：探讨多囊卵巢综合征（PCOS）与子宫内膜异位症、深静脉血栓形成（DVT）和肺栓塞（PE）的关系。方法：这是一项回顾性研究，使用医疗成本和利用项目数据库前瞻性地收集数据。我们从2007年至2014年间住院的12814970名年龄在18岁至49岁的女性患者中研究了PCOS和子宫内膜异位症与DVT和PE之间的关系。结果：我们观察到增加趋势，PCOS相对增加140%（从0.27%到0.65%），DVT相对增加16%（从0.43%到0.50%），PE相对增加39%（从0.23%到0.32%），而子宫内膜异位症相对下降34%（从0.85%到0.56%）。未经调整的分析显示PCOS和VTE之间存在关联，在调整了社会人口学特征和合并症后，这种关联仍然显著(OR=2.16；95%CI 2.00-2.33和2.44；DVT和PE的95%CI分别为2.23-2.67)。子宫内膜异位症和静脉血栓栓塞之间的关系是年龄依赖性的，18-24岁的女性患静脉血栓栓塞的风险增加，而35岁及以上的女性患静脉血栓栓塞的风险降低。结论：我们的研究表明PCOS与VTE之间存在关联，子宫内膜异位症与VTE之间存在年龄依赖性关联。

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Polycystic Ovary Syndrome, Endometriosis and Venous Thromboembolism: A population-based study.

Background: There is a paucity of studies on the association between polycystic ovary syndrome (PCOS) and endometriosis and the occurrence of venous thromboembolism (VTE).

Objective: Our study aimed to evaluate the association between PCOS, endometriosis, deep vein thrombosis (DVT) and pulmonary embolism (PE).

Methods: This was a retrospective study of prospectively collected data using the Healthcare Cost and Utilization Project database. We examined the association between PCOS and endometriosis with DVT and PE from a cohort of 12,814,970 female patients, aged 18 to 49 years, who were hospitalized between 2007 and 2014.

Results: We observed increasing trends, with a relative increase of 140% (from 0.27% to 0.65%) for PCOS, 16% (from 0.43% to 0.50%) for DVT, and 39% (from 0.23% to 0.32%) for PE, whereas we observed a decline by 34% for endometriosis (from 0.85% to 0.56%). The unadjusted analysis showed an association between PCOS and VTE, which remained significant after adjustment for sociodemographic characteristics and comorbidities (OR=2.16; 95%CI 2.00-2.33 and 2.44; 95%CI 2.23-2.67 for DVT and PE, respectively). The association between endometriosis and VTE was age-dependent, with an increased risk of VTE among women 18-24 years whereas this risk was decreased among those 35 years and older.

Conclusion: Our study indicates an association between PCOS and VTE, and an age-dependent association between endometriosis and VTE.

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来源期刊

Gynecologic and Obstetric Investigation 医学-妇产科学

CiteScore

4.20

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.