与严重多灶性肌张力障碍相关的抗二肽基肽酶样蛋白-6 （DPPX）自身免疫性脑炎

IF 1.9 Q3 CLINICAL NEUROLOGY

Clinical Parkinsonism Related Disorders Pub Date : 2025-01-01 DOI:10.1016/j.prdoa.2025.100320

Eric Roddy , Erik Gentry , Victoria Holiday , David Robertson , Peter Hedera

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引用次数: 0

摘要

抗dppx脑炎是一种罕见的自身免疫性脑炎，其特征是针对Kv4.2钾通道亚基的抗体。临床特征包括认知功能障碍、睡眠异常、精神病和癫痫发作。运动症状典型包括肌阵挛、震颤和中线共济失调。DPPX脑炎表现为新发局灶性肌张力障碍，以前没有描述过。

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Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia

Anti-DPPX encephalitis is a rare form of autoimmune encephalitis characterized antibodies against a subunit of Kv4.2 potassium channels. Characteristic clinical features include cognitive dysfunction, parasomnias, psychosis, and seizures. Motor symptoms typically include myoclonus, tremor, and midline ataxia. DPPX encephalitis presenting as new-onset focal dystonia has not been previously described.

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来源期刊

Clinical Parkinsonism Related Disorders Medicine-Neurology (clinical)

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

98 days