Nicolas Giraud , Hilâl Tekatli , Famke L. Schneiders , John R. van Sornsen de Koste , Marco Marzo , Miguel A. Palacios , Suresh Senan
{"title":"中央肺立体定向消融放疗中危险器官邻近:四维计算机断层扫描和磁共振引导屏气传送技术的比较","authors":"Nicolas Giraud , Hilâl Tekatli , Famke L. Schneiders , John R. van Sornsen de Koste , Marco Marzo , Miguel A. Palacios , Suresh Senan","doi":"10.1016/j.phro.2025.100761","DOIUrl":null,"url":null,"abstract":"<div><div>Higher toxicity rates are associated with stereotactic ablative radiotherapy (SABR) to central lung tumors. Breath-hold (BH) magnetic resonance-guided SABR (MR-SABR) can reduce doses to organs at risk (OAR). We quantified the planning target volumes (PTV) to OAR distance in 45 lesions treated using MR-SABR and generated a corresponding four-dimensional computed tomography (4D-CT) based PTV (motion-encompassing internal target volume plus 5 mm). For lesions located ≦3 cm from airways, BH MR-SABR increased the median PTV distance to OAR by 3.7 mm. For lesions ≦3 cm from pericardium, median PTV-OAR separation increased by 2.0 mm with BH. These findings highlight the advantage of BH SABR for central lung tumors.</div></div>","PeriodicalId":36850,"journal":{"name":"Physics and Imaging in Radiation Oncology","volume":"34 ","pages":"Article 100761"},"PeriodicalIF":3.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Organs at risk proximity in central lung stereotactic ablative radiotherapy: A comparison of four-dimensional computed tomography and magnetic resonance-guided breath-hold delivery techniques\",\"authors\":\"Nicolas Giraud , Hilâl Tekatli , Famke L. Schneiders , John R. van Sornsen de Koste , Marco Marzo , Miguel A. Palacios , Suresh Senan\",\"doi\":\"10.1016/j.phro.2025.100761\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Higher toxicity rates are associated with stereotactic ablative radiotherapy (SABR) to central lung tumors. Breath-hold (BH) magnetic resonance-guided SABR (MR-SABR) can reduce doses to organs at risk (OAR). We quantified the planning target volumes (PTV) to OAR distance in 45 lesions treated using MR-SABR and generated a corresponding four-dimensional computed tomography (4D-CT) based PTV (motion-encompassing internal target volume plus 5 mm). For lesions located ≦3 cm from airways, BH MR-SABR increased the median PTV distance to OAR by 3.7 mm. For lesions ≦3 cm from pericardium, median PTV-OAR separation increased by 2.0 mm with BH. These findings highlight the advantage of BH SABR for central lung tumors.</div></div>\",\"PeriodicalId\":36850,\"journal\":{\"name\":\"Physics and Imaging in Radiation Oncology\",\"volume\":\"34 \",\"pages\":\"Article 100761\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics and Imaging in Radiation Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405631625000661\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics and Imaging in Radiation Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405631625000661","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Organs at risk proximity in central lung stereotactic ablative radiotherapy: A comparison of four-dimensional computed tomography and magnetic resonance-guided breath-hold delivery techniques
Higher toxicity rates are associated with stereotactic ablative radiotherapy (SABR) to central lung tumors. Breath-hold (BH) magnetic resonance-guided SABR (MR-SABR) can reduce doses to organs at risk (OAR). We quantified the planning target volumes (PTV) to OAR distance in 45 lesions treated using MR-SABR and generated a corresponding four-dimensional computed tomography (4D-CT) based PTV (motion-encompassing internal target volume plus 5 mm). For lesions located ≦3 cm from airways, BH MR-SABR increased the median PTV distance to OAR by 3.7 mm. For lesions ≦3 cm from pericardium, median PTV-OAR separation increased by 2.0 mm with BH. These findings highlight the advantage of BH SABR for central lung tumors.