Garynthone A-I、云南藤黄不同骨架PPAPs及其免疫抑制活性研究

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-04-04 DOI:10.1039/d5qo00414d

Zifeng Guo, Pengxue Ji, Shengnan Yang, Zhiyuan Li, Yongbo Yu, Jingming Jia, Anhua Wang

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引用次数: 0

摘要

本研究报道了云南野鸡中17个PPAPs的分离和结构表征，包括具有前所未有的5-五戊环[7,3,1,14,7,16,11,1,1,6]五烷骨架的新型Garynthone A(1)，以及8个先前未描述的PPAPs（2-9）。采用核磁共振数据分析、耦合常数分析、量子计算、修正mosher法、x射线单晶晶体学、ECD光谱、计算机辅助结构解析（CASE）、DP5/DP4概率分析等方法对其结构进行表征，并对garcoblone E的结构进行修正（10）。化合物(+)-2、3、(+)-4、5、（±）-6、（±）-7、9、14、16和17对t细胞增殖具有中等抑制作用，IC50值为2.02 ~ 19.41 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Garynthone A–I, PPAPs with diverse skeletons isolated from Garcinia yunnanensis and their immunosuppressive activity

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Garynthone A–I, PPAPs with diverse skeletons isolated from Garcinia yunnanensis and their immunosuppressive activity

This study reports the isolation and structural characterization of 17 PPAPs from G. yunnanensis, including the novel Garynthone A (1) featuring an unprecedented 5-oxapentacyclo [7,3,1,1^4,7,1^6,11,0^1,6] pentadecane skeleton, along with eight previously undescribed PPAPs (2–9). NMR data analysis, coupling constants analysis, quantum calculations, modified mosher's method, X-ray single-crystal crystallography, ECD spectra, computer-assisted structure elucidation (CASE), and DP5/DP4 probability analyses were employed to characterize their structures and revise the structure of garcoblone E (10). Compounds (+)-2, 3, (+)-4, 5, (±)-6, (±)-7, 9, 14, 16, and 17 exhibited moderate inhibition of T-cell proliferation, with IC₅₀ values ranging from 2.02 to 19.41 μM.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.