{"title":"糖化白蛋白和c反应蛋白/总白蛋白比值的估计水平可以在表面健康的人群中区分糖尿病前期,并预测脂肪性肝炎和心脏风险的易感性。","authors":"Rizk S Sarhan, Raafat R Mohammed","doi":"10.37796/2211-8039.1639","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Prediabetes precedes Type-2 diabetes development, is characterized by impaired glucose tolerance (IGT) as judged by the 75-g oral glucose tolerance test (75-OGTT) and is associated with higher cardiac risk (CR), dyslipidemia, hepatosteatosis (HS) and cancer.</p><p><strong>Aims: </strong>The study aimed to determine the distinguishing ability of estimated levels of glycated albumin (GA) and hemoglobin A1c (HbA1c), and serum C-reactive protein (CRP) and serum total albumin (TA) levels for prediabetic out of apparently healthy subjects.</p><p><strong>Methods: </strong>IGT was diagnosed if fasting blood glucose (FBG) was 100-125 mg/dl and if < 100 mg/dl subject is normal glucose tolerant (NGT). CR, HS and insulin resistance (IR) were suggested if the calculated atherogenic index of plasma (AIP) was >0.1, HS index (HSI) was >36 with high computerized hepatorenal index (HRI) and the homeostasis model assessment of IR (HOMA-IR) score was >2, respectively.</p><p><strong>Results: </strong>253 subjects (50.8%) had IGT and were older, more obese and mainly females. IGT had higher GA%, HOMA-IR score, serum CRP and lower TA with high CRP/TA ratio (CAR) than NGT. The frequency of subjects had AIP>0.1, HSI>36 and high HRI was significantly higher among IGT subjects. Statistical analyses defined high GA% and CAR as predictors for IGT, HOMA-IR>36 and AIP score >0.1, while high CAR is the only predictor for HSI score >36 and high HIR score.</p><p><strong>Conclusion: </strong>Prediabetes is not uncommon and high GA% and CAR might differentiate them among the apparently healthy population, and could predict those at increased risk for IR, HS and at CR.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"42-52"},"PeriodicalIF":2.1000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959985/pdf/","citationCount":"0","resultStr":"{\"title\":\"Estimated levels of glycated albumin and C-reactive protein/total albumin ratio might distinguish prediabetics among the apparently healthy people and predict the vulnerability for development of steatohepatitis and cardiac risk.\",\"authors\":\"Rizk S Sarhan, Raafat R Mohammed\",\"doi\":\"10.37796/2211-8039.1639\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Prediabetes precedes Type-2 diabetes development, is characterized by impaired glucose tolerance (IGT) as judged by the 75-g oral glucose tolerance test (75-OGTT) and is associated with higher cardiac risk (CR), dyslipidemia, hepatosteatosis (HS) and cancer.</p><p><strong>Aims: </strong>The study aimed to determine the distinguishing ability of estimated levels of glycated albumin (GA) and hemoglobin A1c (HbA1c), and serum C-reactive protein (CRP) and serum total albumin (TA) levels for prediabetic out of apparently healthy subjects.</p><p><strong>Methods: </strong>IGT was diagnosed if fasting blood glucose (FBG) was 100-125 mg/dl and if < 100 mg/dl subject is normal glucose tolerant (NGT). CR, HS and insulin resistance (IR) were suggested if the calculated atherogenic index of plasma (AIP) was >0.1, HS index (HSI) was >36 with high computerized hepatorenal index (HRI) and the homeostasis model assessment of IR (HOMA-IR) score was >2, respectively.</p><p><strong>Results: </strong>253 subjects (50.8%) had IGT and were older, more obese and mainly females. IGT had higher GA%, HOMA-IR score, serum CRP and lower TA with high CRP/TA ratio (CAR) than NGT. The frequency of subjects had AIP>0.1, HSI>36 and high HRI was significantly higher among IGT subjects. Statistical analyses defined high GA% and CAR as predictors for IGT, HOMA-IR>36 and AIP score >0.1, while high CAR is the only predictor for HSI score >36 and high HIR score.</p><p><strong>Conclusion: </strong>Prediabetes is not uncommon and high GA% and CAR might differentiate them among the apparently healthy population, and could predict those at increased risk for IR, HS and at CR.</p>\",\"PeriodicalId\":51650,\"journal\":{\"name\":\"BioMedicine-Taiwan\",\"volume\":\"15 1\",\"pages\":\"42-52\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959985/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BioMedicine-Taiwan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37796/2211-8039.1639\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioMedicine-Taiwan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37796/2211-8039.1639","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Estimated levels of glycated albumin and C-reactive protein/total albumin ratio might distinguish prediabetics among the apparently healthy people and predict the vulnerability for development of steatohepatitis and cardiac risk.
Background: Prediabetes precedes Type-2 diabetes development, is characterized by impaired glucose tolerance (IGT) as judged by the 75-g oral glucose tolerance test (75-OGTT) and is associated with higher cardiac risk (CR), dyslipidemia, hepatosteatosis (HS) and cancer.
Aims: The study aimed to determine the distinguishing ability of estimated levels of glycated albumin (GA) and hemoglobin A1c (HbA1c), and serum C-reactive protein (CRP) and serum total albumin (TA) levels for prediabetic out of apparently healthy subjects.
Methods: IGT was diagnosed if fasting blood glucose (FBG) was 100-125 mg/dl and if < 100 mg/dl subject is normal glucose tolerant (NGT). CR, HS and insulin resistance (IR) were suggested if the calculated atherogenic index of plasma (AIP) was >0.1, HS index (HSI) was >36 with high computerized hepatorenal index (HRI) and the homeostasis model assessment of IR (HOMA-IR) score was >2, respectively.
Results: 253 subjects (50.8%) had IGT and were older, more obese and mainly females. IGT had higher GA%, HOMA-IR score, serum CRP and lower TA with high CRP/TA ratio (CAR) than NGT. The frequency of subjects had AIP>0.1, HSI>36 and high HRI was significantly higher among IGT subjects. Statistical analyses defined high GA% and CAR as predictors for IGT, HOMA-IR>36 and AIP score >0.1, while high CAR is the only predictor for HSI score >36 and high HIR score.
Conclusion: Prediabetes is not uncommon and high GA% and CAR might differentiate them among the apparently healthy population, and could predict those at increased risk for IR, HS and at CR.