环状rna：治疗乳腺癌的一种新的潜在策略

IF 5.7 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.3389/fimmu.2025.1563655

Pangzhou Chen, Jinhui Zhang, Song Wu, Xiaoyu Zhang, Wen Zhou, Ziyun Guan, Hailin Tang

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引用次数: 0

摘要

乳腺癌是世界上最常见的恶性肿瘤之一，三阴性乳腺癌（TNBC）是最具侵袭性的亚型，缺乏有效的治疗选择。环状rna （circRNAs）是非编码rna，在包括乳腺癌在内的肿瘤的发展中起着至关重要的作用。本文综述了circrna在乳腺癌中的研究进展，主要从四个方面进行综述：1)乳腺癌的流行病学、分类和治疗；2)环状rna的结构、发现过程、特征、形成和功能；3) circRNAs在乳腺癌细胞和免疫微环境（尤其是TNBC）中的表达、机制、临床相关性和最新研究进展；4) circrna在BC研究中应用的挑战和未来前景。

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CircRNAs: a novel potential strategy to treat breast cancer.

Breast cancer is among the most prevalent malignant tumors worldwide, with triple-negative breast cancer (TNBC) being the most aggressive subtype and lacking effective treatment options. Circular RNAs (circRNAs) are noncoding RNAs that play crucial roles in the development of tumors, including breast cancer. This article examines the progress of research on circRNAs in breast cancer, focusing on four main areas: 1) breast cancer epidemiology, classification, and treatment; 2) the structure, discovery process, characteristics, formation, and functions of circRNAs; 3) the expression, mechanisms, clinical relevance, and recent advances in the study of circRNAs in breast cancer cells and the immune microenvironment, particularly in TNBC; and 4) the challenges and future prospects of the use of circRNAs in BC research.

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来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.