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引用次数: 0
摘要
生物分子的化学修饰是控制分子功能的重要调控机制。虽然长期以来研究的重点是DNA和蛋白质,但随着检测技术的进步,RNA修饰最近引起了人们的极大兴趣。在肿瘤学中,许多研究已经发现了包括m6A、m1A、m5C、m7G、假尿嘧啶化和A to I编辑在内的RNA修饰失调,导致下游通路中断。随着肿瘤微环境概念的日益突出,研究越来越多地探讨了RNA修饰在这一背景下的作用,重点关注癌细胞、免疫细胞、基质细胞和其他成分之间的相互作用。本文从肿瘤-免疫周期的角度对肿瘤微环境中的RNA修饰进行综述。包括外泌体在内的细胞外RNA修饰以及微生物组在RNA修饰中的影响是潜在的研究问题。此外,RNA修饰酶包括FTO, ALKBH5, METTL3, PUS7正在研究中,作为潜在的生物标志物和与免疫疗法联合的靶点。adc和修饰RNA的模拟物可能是潜在的新型药物。本文综述了RNA修饰在肿瘤微环境中的调控作用。
RNA modifications in the tumor microenvironment: insights into the cancer-immunity cycle and beyond.
The chemical modification of biological molecules is a critical regulatory mechanism for controlling molecular functions. Although research has long focused on DNA and proteins, RNA modifications have recently attracted substantial interest with the advancement in detection technologies. In oncology, many studies have identified dysregulated RNA modifications including m6A, m1A, m5C, m7G, pseudouridylation and A to I editing, leading to disrupted downstream pathways. As the concept of the tumor microenvironment has gained prominence, studies have increasingly examined the role of RNA modifications in this context, focusing on interactions among cancer cells, immune cells, stromal cells, and other components. Here we review the RNA modifications in the tumor microenvironment through the perspective of the Cancer-Immunity Cycle. The extracellular RNA modifications including exosomes and influence of microbiome in RNA modifications are potential research questions. Additionally, RNA modifying enzymes including FTO, ALKBH5, METTL3, PUS7 are under investigation as potential biomarkers and targets for combination with immunotherapies. ADCs and mimetics of modified RNA could be potential novel drugs. This review discusses the regulatory roles of RNA modifications within the tumor microenvironment.
期刊介绍:
Experimental Hematology & Oncology is an open access journal that encompasses all aspects of hematology and oncology with an emphasis on preclinical, basic, patient-oriented and translational research. The journal acts as an international platform for sharing laboratory findings in these areas and makes a deliberate effort to publish clinical trials with 'negative' results and basic science studies with provocative findings.
Experimental Hematology & Oncology publishes original work, hypothesis, commentaries and timely reviews. With open access and rapid turnaround time from submission to publication, the journal strives to be a hub for disseminating new knowledge and discussing controversial topics for both basic scientists and busy clinicians in the closely related fields of hematology and oncology.