Delta-8-THC警告标签对青少年感知中毒、危害和易感性的影响

IF 4.4 2区医学 Q1 SUBSTANCE ABUSE

International Journal of Drug Policy Pub Date : 2025-04-04 DOI:10.1016/j.drugpo.2025.104781

Alyssa F. Harlow , Adam M. Leventhal , Jessica L. Barrington-Trimis

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引用次数: 0

摘要

背景：青少年使用含有精神活性物质Δ8-tetrahydrocannabinol （δ -8- thc）的大麻衍生大麻产品在美国很普遍。Delta-8-THC是令人陶醉的，然而Delta-8-THC产品在美国许多州不受警告标签要求的约束。本实验确定了假设的大麻警告标签对delta-8-THC口香糖和vape产品感知的影响。方法在2023年对3,647名南加州青少年进行的一项调查中嵌入了一项混合的受试者间实验。参与者被随机分配在三种条件下查看delta-8-THC可食用产品和vape产品的照片（对照[未经修改]与标准尺寸警告标签[通用大麻警告标志，政府警告文字，使用说明和大麻注入的文字]与更大的警告标签[与标准标签相同，带有更大的大麻警告标志]）。在图像曝光后，我们测量了预期中毒，感知伤害和使用各自的δ -8- thc产品的易感性。评估了产品类型和大麻使用状况的适度性。结果看到带有较大警告标签的delta-8-THC产品的青少年（与对照组相比）报告了更大的预期中毒（Mean Difference[MD]==2.50, 95 %CI= 0.85-4.14），并且delta-8-THC产品对其健康有害的可能性更高（风险比[RR]=1.07, 95 %CI= 1.02-1.12），至少有一定的风险（RR=1.03, 95 %CI: 1.01-1.05），并且与大麻相同或更有害（RR=1.04, 95 %CI= 1.01-1.07）。警示标签对易感性没有影响，大警示标签与标准警示标签之间的差异很小。对于delta-8-THC口香糖（vs. vape）和从未使用大麻的青少年，警告标签对感知伤害的影响更强(相互作用p值<；0.05)。结论要求δ -8-四氢大麻酚产品符合大麻产品的标签要求，可能会增加cannabis-naïve青少年对其麻醉作用和危害的了解。代替联邦法规，各州应考虑实施delta-8-THC法规，如标签要求，以促进安全性并减少对青少年的潜在伤害。

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Impact of Delta-8-THC warning labels on perceived intoxication, harm, and susceptibility among adolescents

Background

Youth use of hemp-derived cannabis products containing psychoactive Δ8-tetrahydrocannabinol (delta-8-THC) is prevalent in the United States (US). Delta-8-THC is intoxicating, however delta-8-THC products are not subject to warning labeling requirements in many US states. This experiment determined effects of hypothetical cannabis warning labels on perception of delta-8-THC gummies and vape products.

Methods

A mixed within-between-subject experiment was embedded into a 2023 survey of 3,647 Southern California adolescents. Participants were randomized to view photos of delta-8-THC edible and vape products under one of three conditions (control [unmodified] vs. standard size warning label [universal cannabis warning symbol, government warning text, instructions for use, and text stating it was cannabis-infused] vs. larger warning label [same as standard label with larger cannabis warning symbol]). After image exposure, we measured anticipated intoxication, perceived harm, and susceptibility to use the respective delta-8-THC products. Moderation by product type and cannabis use status were assessed.

Results

Youth who viewed delta-8-THC products with larger warning labels (vs. control) reported greater anticipated intoxication (Mean Difference[MD]==2.50, 95 %CI=0.85–4.14 on 100-point scale), and higher likelihood that delta-8-THC products are bad for their health (Risk Ratio[RR]=1.07, 95 %CI=1.02–1.12), pose at least some risk (RR=1.03, 95 %CI: 1.01–1.05), and are the same or more harmful than marijuana (RR=1.04, 95 %CI=1.01–1.07). There were no warning label effects on susceptibility and minimal differences across outcomes between larger versus standard warning labels. Warning label effects on perceived harm were stronger for delta-8-THC gummies (vs. vape) and for never vs. ever cannabis-using youth (interaction p-values < 0.05).

Conclusion

Requiring delta-8-THC products to conform to labeling requirements for cannabis products may increase understanding of their intoxicating effects and harm among cannabis-naïve youth. In lieu of federal regulations, states should consider implementation of delta-8-THC regulations such as labeling requirements that promote safety and reduce potential harm to youth.

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来源期刊

International Journal of Drug Policy SUBSTANCE ABUSE-

CiteScore

7.80

自引率

11.40%

发文量

307

审稿时长

62 days

期刊介绍： The International Journal of Drug Policy provides a forum for the dissemination of current research, reviews, debate, and critical analysis on drug use and drug policy in a global context. It seeks to publish material on the social, political, legal, and health contexts of psychoactive substance use, both licit and illicit. The journal is particularly concerned to explore the effects of drug policy and practice on drug-using behaviour and its health and social consequences. It is the policy of the journal to represent a wide range of material on drug-related matters from around the world.