镍/光氧化还原协同催化烯烃的三组分1,2-碳炔基化

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-24 DOI:10.1021/acs.orglett.5c0047110.1021/acs.orglett.5c00471

Lujing Niu, Shengzhou Jin, Meiqi Zhu, Lanfen Wang and Dingyi Wang*,

{"title":"镍/光氧化还原协同催化烯烃的三组分1,2-碳炔基化","authors":"Lujing Niu, Shengzhou Jin, Meiqi Zhu, Lanfen Wang and Dingyi Wang*, ","doi":"10.1021/acs.orglett.5c0047110.1021/acs.orglett.5c00471","DOIUrl":null,"url":null,"abstract":"<p >A photoredox/nickel dual catalytic system was developed for the three-component 1,2-carboalkynylation of alkenes. This redox-neutral protocol enables the efficient and divergent synthesis of aliphatic alkynes in high yields with excellent regioselectivity, using readily available starting materials. The resulting adducts can be readily transformed into terminal alkynes, facilitating diverse downstream transformations. Mechanistic studies were performed to elucidate the preferred pathway of this alkene difunctionalization process.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"27 13","pages":"3183–3187 3183–3187"},"PeriodicalIF":5.0000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Three-Component 1,2-Carboalkynylation of Alkenes Via Cooperative Nickel/Photoredox Catalysis\",\"authors\":\"Lujing Niu, Shengzhou Jin, Meiqi Zhu, Lanfen Wang and Dingyi Wang*, \",\"doi\":\"10.1021/acs.orglett.5c0047110.1021/acs.orglett.5c00471\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >A photoredox/nickel dual catalytic system was developed for the three-component 1,2-carboalkynylation of alkenes. This redox-neutral protocol enables the efficient and divergent synthesis of aliphatic alkynes in high yields with excellent regioselectivity, using readily available starting materials. The resulting adducts can be readily transformed into terminal alkynes, facilitating diverse downstream transformations. Mechanistic studies were performed to elucidate the preferred pathway of this alkene difunctionalization process.</p>\",\"PeriodicalId\":54,\"journal\":{\"name\":\"Organic Letters\",\"volume\":\"27 13\",\"pages\":\"3183–3187 3183–3187\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-03-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.orglett.5c00471\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.orglett.5c00471","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

建立了一种光氧化还原/镍双催化体系，用于烯烃的三组分1,2-碳烷基化反应。这种氧化还原-中性的方案使脂肪族炔的高效和多样化的合成具有优异的区域选择性，高产率高，使用现成的起始材料。所得到的加合物可以很容易地转化为末端炔，便于多种下游转化。进行了机理研究，以阐明该烯烃双官能化过程的优选途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Three-Component 1,2-Carboalkynylation of Alkenes Via Cooperative Nickel/Photoredox Catalysis

查看原文本刊更多论文

Three-Component 1,2-Carboalkynylation of Alkenes Via Cooperative Nickel/Photoredox Catalysis

A photoredox/nickel dual catalytic system was developed for the three-component 1,2-carboalkynylation of alkenes. This redox-neutral protocol enables the efficient and divergent synthesis of aliphatic alkynes in high yields with excellent regioselectivity, using readily available starting materials. The resulting adducts can be readily transformed into terminal alkynes, facilitating diverse downstream transformations. Mechanistic studies were performed to elucidate the preferred pathway of this alkene difunctionalization process.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.