乙烯基阳离子催化铜催化三炔环化

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-27 DOI:10.1021/acs.orglett.5c0076910.1021/acs.orglett.5c00769

Chen Luo, Yan-Xin Zheng, Sheng-Biao Ji, Huan-Chao Song, Guang-Hui Wang*, Feng-Lin Hong, Zhou Xu*, Binju Wang and Long-Wu Ye*,

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引用次数: 0

摘要

在这里，我们描述了一个有效的铜催化环化通过乙烯基阳离子中间体的三炔。该反应在温和的反应条件下一步合成了三个新环，从而实现了实用和原子经济的有价多环吡咯合成。所提出的反应机理显示了炔烃的有序和区域选择性反应。此外，这种不对称三环环化的可能性也出现了。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper-Catalyzed Triyne Cyclization via Vinyl Cations

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Copper-Catalyzed Triyne Cyclization via Vinyl Cations

Herein, we describe an efficient copper-catalyzed cyclization of triynes via vinyl cation intermediates. The reaction leads to the practical and atom-economical synthesis of valuable polycyclic pyrroles by constructing three new rings in one step under mild reaction conditions. The proposed reaction mechanism shows the ordered and regioselective reaction of alkynes. Moreover, the possibility of such an asymmetric triyne cyclization also emerges.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.