2,3-烯醇的电化学环化

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-03 DOI:10.1021/acs.orglett.5c00193

Wenyao Li, Dong Huang, Zhuowei Xu, Zhongshuo Zhang, Ying Wang, Hao Yu, Shengming Ma

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引用次数: 0

摘要

实现了丙烯醇的高效电化学溴环化反应，合成了螺环2,5-二氢呋喃。该反应使用市售无毒的KBr作为溴化源，在露天条件下进行了简单的设置。值得注意的是，光活性2,3-烯醇无需外消旋即可得到光活性产物，进一步提高了合成实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrochemical Cyclization of 2,3-Allenols

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Electrochemical Cyclization of 2,3-Allenols

An efficient electrochemical bromocyclization of allenols has been realized for the synthesis of spirocyclic 2,5-dihydrofurans. The reaction used commercially available and nontoxic KBr as the brominating source in a simple setup under open-air conditions. Notably, optically active products can be obtained from optically active 2,3-allenols without any racemization, further enhancing the synthetic utility.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.