Megan Clark, Noah Daniel, Petr Bruza, Rongxiao Zhang, Lesley Jarvis, P. Jack Hoopes, David Gladstone
{"title":"用于UHDR电子束实时、全场脉冲表面剂量测定的成像系统。","authors":"Megan Clark, Noah Daniel, Petr Bruza, Rongxiao Zhang, Lesley Jarvis, P. Jack Hoopes, David Gladstone","doi":"10.1002/mp.17784","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The interest in ultra-high dose rate (UHDR) radiation therapy (RT) has grown due to its potential to spare normal tissue. However, clinical application is hindered by dosimetry challenges, as current irradiators and dosimeters are not designed for UHDR's high fluence. To ensure safe treatment and accurate dose delivery, real-time dose and dose rate quantification methods are essential.</p>\n </section>\n \n <section>\n \n <h3> Purpose</h3>\n \n <p>We propose a novel scintillation imaging system for in vivo, pulse-by-pulse surface dose monitoring during delivery with a UHDR-capable Mobetron (IntraOp LLC Sunnyvale, CA, USA) system. This setup aims to measure entrance beam dose with high 2D spatial and temporal resolution.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A modified collimating cone was 3D printed to house the imaging lens. The system featured a 90° sinuscope endoscope attached to a CMOS camera, was gated by the Mobetron's magnetron output signal, and captured light from a scintillator placed on the treatment surface. Three scintillator types were tested for their emission intensity and decay time. Dose and dose rate linearity studies were performed using various pulse lengths and repetition frequencies, respectively, and the imaging data were compared to an EDGE diode detector (SunNuclear Melbourne, FL, USA) and the Mobetron beam-current transformer (BCT) measurements.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Dose (<i>R</i><sup>2 </sup>= 0.993) and dose rate (within 2%) were linear, and the temporal beam structure agreed with the diode and BCT data, as evident by the fact that it was successfully gated such that it captured each pulse during testing. Dose per pulse measurements agreed with diode and BCT data within 2.0 ± 1.2 cGy (0.6% ± 0.3%) and 2.5 ± 1.0 cGy (1.1% ± 0.4%), respectively.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The developed imaging system met the criteria for measuring entrance beam dose with high spatial and temporal resolution, offering a promising in vivo dosimetry method for UHDR RT in preclinical and clinical trials.</p>\n </section>\n </div>","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 6","pages":"5026-5031"},"PeriodicalIF":3.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Imaging system for real-time, full-field pulse-by-pulse surface dosimetry of UHDR electron beams\",\"authors\":\"Megan Clark, Noah Daniel, Petr Bruza, Rongxiao Zhang, Lesley Jarvis, P. Jack Hoopes, David Gladstone\",\"doi\":\"10.1002/mp.17784\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The interest in ultra-high dose rate (UHDR) radiation therapy (RT) has grown due to its potential to spare normal tissue. However, clinical application is hindered by dosimetry challenges, as current irradiators and dosimeters are not designed for UHDR's high fluence. To ensure safe treatment and accurate dose delivery, real-time dose and dose rate quantification methods are essential.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>We propose a novel scintillation imaging system for in vivo, pulse-by-pulse surface dose monitoring during delivery with a UHDR-capable Mobetron (IntraOp LLC Sunnyvale, CA, USA) system. This setup aims to measure entrance beam dose with high 2D spatial and temporal resolution.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A modified collimating cone was 3D printed to house the imaging lens. The system featured a 90° sinuscope endoscope attached to a CMOS camera, was gated by the Mobetron's magnetron output signal, and captured light from a scintillator placed on the treatment surface. Three scintillator types were tested for their emission intensity and decay time. Dose and dose rate linearity studies were performed using various pulse lengths and repetition frequencies, respectively, and the imaging data were compared to an EDGE diode detector (SunNuclear Melbourne, FL, USA) and the Mobetron beam-current transformer (BCT) measurements.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Dose (<i>R</i><sup>2 </sup>= 0.993) and dose rate (within 2%) were linear, and the temporal beam structure agreed with the diode and BCT data, as evident by the fact that it was successfully gated such that it captured each pulse during testing. 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Imaging system for real-time, full-field pulse-by-pulse surface dosimetry of UHDR electron beams
Background
The interest in ultra-high dose rate (UHDR) radiation therapy (RT) has grown due to its potential to spare normal tissue. However, clinical application is hindered by dosimetry challenges, as current irradiators and dosimeters are not designed for UHDR's high fluence. To ensure safe treatment and accurate dose delivery, real-time dose and dose rate quantification methods are essential.
Purpose
We propose a novel scintillation imaging system for in vivo, pulse-by-pulse surface dose monitoring during delivery with a UHDR-capable Mobetron (IntraOp LLC Sunnyvale, CA, USA) system. This setup aims to measure entrance beam dose with high 2D spatial and temporal resolution.
Methods
A modified collimating cone was 3D printed to house the imaging lens. The system featured a 90° sinuscope endoscope attached to a CMOS camera, was gated by the Mobetron's magnetron output signal, and captured light from a scintillator placed on the treatment surface. Three scintillator types were tested for their emission intensity and decay time. Dose and dose rate linearity studies were performed using various pulse lengths and repetition frequencies, respectively, and the imaging data were compared to an EDGE diode detector (SunNuclear Melbourne, FL, USA) and the Mobetron beam-current transformer (BCT) measurements.
Results
Dose (R2 = 0.993) and dose rate (within 2%) were linear, and the temporal beam structure agreed with the diode and BCT data, as evident by the fact that it was successfully gated such that it captured each pulse during testing. Dose per pulse measurements agreed with diode and BCT data within 2.0 ± 1.2 cGy (0.6% ± 0.3%) and 2.5 ± 1.0 cGy (1.1% ± 0.4%), respectively.
Conclusions
The developed imaging system met the criteria for measuring entrance beam dose with high spatial and temporal resolution, offering a promising in vivo dosimetry method for UHDR RT in preclinical and clinical trials.
期刊介绍:
Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments
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