减肥手术后地塞米松抑制试验的准确性受损:对术后皮质醇解释的影响。

IF 5.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
European Journal of Endocrinology Pub Date : 2025-03-27 Epub Date: 2025-03-25 DOI:10.1093/ejendo/lvaf053
Anna Casteràs, Enzamaria Fidilio, Marta Comas, Alba Zabalegui, Vanesa Flores, Marina Giralt, Noelia Díaz-Troyano, Roser Ferrer, Ramon Vilallonga, Andreea Ciudin, Betina Biagetti
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引用次数: 0

摘要

重要性:减肥手术(BS)对1mg地塞米松抑制试验(DST)性能的影响尚未得到很好的证实。目的:(1)评价一组BS患者术前和术后2年DST的个体内结果;(2)评价血浆地塞米松水平等因素对DST可靠性的影响。方法:我们进行了一项前瞻性纵向研究,包括38名在BS前和BS后2年评估DST的受试者。我们还比较了3组患者的DST结果、血浆地塞米松水平和相关因素:BS后2年的前队列患者(n = 21)、无BS的重度肥胖患者(pw;结果:与先前相比,bs后患者在DST后的皮质醇水平更高(0.9 vs 0.7µg/dL;P < 0.01)。在没有自主皮质醇分泌的情况下,4名bs后个体的皮质醇水平为bb0 1.8µg/dL。bs后患者血浆地塞米松水平(1.9 ng/dL)明显低于未手术的pwO (3.7 ng/dL)和健康对照组(4.0 ng/mL), P < 0.01。多因素分析确定BS (β = -1.258, P = 0.01)和性激素结合球蛋白水平(β = -)。013, P = .04)作为血浆地塞米松浓度的重要独立预测因子。结论:与未手术患者相比,bs后患者dst后皮质醇水平较高,血浆地塞米松浓度较低,可能导致假阳性结果。这些发现强调需要考虑地塞米松测量来增强bs后患者的DST解释。需要进一步的研究在更广泛的人群中验证这些发现。潜在的机制需要探索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impaired accuracy of the dexamethasone suppression test after bariatric surgery: implications for post-surgical cortisol interpretation.

Importance: The impact of bariatric surgery (BS) on the performance of the 1 mg dexamethasone suppression test (DST) is not well established.

Objective: (1) To evaluate the intraindividual results of the DST in a group of patients before and 2 years after BS, and (2) to assess plasma dexamethasone levels and other factors influencing the reliability of the DST.

Methods: We conducted a prospective longitudinal study, including 38 subjects evaluating DST before and 2 years after BS. We also compared DST results, plasma dexamethasone levels, and related factors across 3 groups: individuals of the previous cohort 2 years post-BS (n = 21), patients with severe obesity without BS (pwO; n = 10), and healthy controls (n = 7).

Results: Post-BS patients had higher cortisol levels after DST compared with prior (0.9 vs 0.7 µg/dL; P < .01). Four individuals post-BS had cortisol levels >1.8 µg/dL in the absence of autonomous cortisol secretion. Plasma dexamethasone levels were significantly lower in post-BS patients (1.9 ng/dL) compared with non-operated pwO (3.7 ng/dL) and healthy controls (4.0 ng/mL), P < .01. Multivariate analysis identified BS (β = -1.258, P = .01) and sex hormone-binding globulin levels (β = -.013, P = .04) as significant independent predictors of plasma dexamethasone concentrations.

Conclusion: Post-BS subjects showed higher post-DST cortisol levels and reached lower plasma dexamethasone concentration compared with non-operated individuals, which may lead to false-positive results. These findings highlight the need to consider dexamethasone measurements to enhance DST interpretation in post-BS patients. Further studies are necessary to validate these findings in broader populations. The underlying mechanisms need to be explored.

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来源期刊
European Journal of Endocrinology
European Journal of Endocrinology 医学-内分泌学与代谢
CiteScore
9.80
自引率
3.40%
发文量
354
审稿时长
1 months
期刊介绍: European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.
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