慢性甲状旁腺功能减退的心血管状态:168例患者的系统横断面评估。

IF 5.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Carmina Teresa Fuss, Karen Gronemeyer, Franca Hermes, Marcus Dörr, Benedikt Schmid, Caroline Morbach, Lena Schmidbauer, Nicolas Schlegel, Martin Fassnacht, Ann Cathrin Koschker, Peter Nordbeck, Anke Hannemann, Stefanie Hahner
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引用次数: 0

摘要

目的:慢性甲状旁腺功能减退症(hypoPT)患者的长期并发症如肾脏疾病是众所周知的,但心血管合并症的风险尚不清楚。本研究全面评估了与匹配对照组相比,hypoPT患者的心血管参数。设计:横断面队列研究,纳入168例慢性hypoPT患者。方法:对患者进行心电图、血压测量和超声心动图检查。对来自德国波美拉尼亚人口健康研究(SHIP-TREND)和“心衰A- b期特征和病程”(STAAB)队列的个体进行1:3倾向评分匹配。结果:HypoPT显示收缩压(128 vs 125 mm Hg, P = 0.02)和舒张压(83 vs 77 mm Hg, P < 0.01)显著升高。两组间抗高血压药物的摄入量相似。QTc间期明显延长(438 ms vs 420 ms, P < 0.01),其中hypoPT患者的QTc间期延长更为频繁(24% vs 6%, P < 0.01)。有趣的是,超声心动图显示,hypoopt患者的左室质量指数明显较低(28比43 g/m2.7, P < 0.01),左室肥厚发生率较低(7%比41%,P < 0.01),但左室射血分数相似(P = 0.48)。HypoPT患者二尖瓣狭窄发生率(20% vs 0%, P < 0.01)和主动脉瓣狭窄发生率(7% vs 2%, P < 0.01)较高。与STAAB比较证实动脉高血压患病率增加,心肌质量指数降低。结论:hypoPT患者尽管有既定的治疗方法,但QTc间期延长的发生率更高,高血压的发病率也增加。相反,超声心动图显示,hypoPT患者左心室体积较小,左心室肥厚发生率较低,但瓣膜狭窄发生率较高。建议定期监测高血压、QTc间期延长和瓣膜狭窄,以降低心血管疾病的风险。临床试验注册号:NCT05585593。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiovascular status in chronic hypoparathyroidism: a systematic cross-sectional assessment in 168 patients.

Objective: Long-term complications such as renal diseases are well known in patients with chronic hypoparathyroidism (hypoPT), but risk of cardiovascular comorbidity remains less clear. This study comprehensively assessed cardiovascular parameters in hypoPT compared to matched controls.

Design: Cross-sectional cohort study involving 168 patients with chronic hypoPT.

Methods: Patients underwent electrocardiograms, blood pressure measurements, and echocardiography. A 1:3 propensity score matching was performed with individuals from the German population-based Study of Health in Pomerania (SHIP-TREND) and the "Characteristics and Course of Heart Failure Stages A-B" (STAAB) cohort.

Results: HypoPT showed significantly higher systolic (128 vs 125 mm Hg, P = .02) and diastolic blood pressures (83 vs 77 mm Hg, P < .01). Intake of antihypertensives was similar between groups. The QTc interval was markedly prolonged (438 vs 420 ms, P < .01) with QTc interval prolongation occurring significantly more frequently in hypoPT (24% vs 6%, P < .01). Interestingly, echocardiography revealed significantly lower left ventricular mass index (28 vs 43 g/m2.7, P < .01) and less frequent left ventricular hypertrophy (7%% vs 41%, P < .01) in hypoPT but comparable left ventricular ejection fraction (P = .48). HypoPT patients had higher prevalence of mitral (20 vs 0%, P < .01) and aortic valve stenoses (7 vs 2%, P < .01). Comparison with STAAB confirmed the increased prevalence of arterial hypertension and reduced myocardial mass indices.

Conclusions: Patients with hypoPT exhibit a higher prevalence of QTc interval prolongation despite established therapy and an increased incidence of hypertension. Conversely, echocardiography revealed lower left ventricular mass and less frequent left ventricular hypertrophy in hypoPT, but higher prevalence of valve stenosis. Regular monitoring of hypertension, QTc interval prolongation, and valve stenosis is recommended to reduce the risk of cardiovascular diseases.

Clinical trial registration number: NCT05585593.

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来源期刊
European Journal of Endocrinology
European Journal of Endocrinology 医学-内分泌学与代谢
CiteScore
9.80
自引率
3.40%
发文量
354
审稿时长
1 months
期刊介绍: European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.
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