Emma Rullo, Sabina Barresi, Sabrina Rossi, Sara Patrizi, Evelina Miele, Marta Barisella, Michela Casanova, Andrea Ferrari, Stefano Chiaravalli, Gloria Pelizzo, Rita Alaggio
{"title":"表皮生长因子受体-KDD肌纤维母细胞瘤还是先天性支气管周围肌纤维母细胞瘤（CPMT）？一例具有异常组织学特征的先天性肌成纤维细胞肿瘤的报告","authors":"Emma Rullo, Sabina Barresi, Sabrina Rossi, Sara Patrizi, Evelina Miele, Marta Barisella, Michela Casanova, Andrea Ferrari, Stefano Chiaravalli, Gloria Pelizzo, Rita Alaggio","doi":"10.1002/gcc.70032","DOIUrl":null,"url":null,"abstract":"<p>EGFR-kinase-domain duplication (KDD) has been reported in Infantile fibrosarcoma-like myofibroblastic tumors and cellular mesoblastic nephroma. We report a pulmonary neoplasm with EGFR-(KDD) and infantile fibrosarcoma-like histologic features in a female infant with an unusual clinical and histologic evolution, characterized by persistent disease with morphologic features of Congenital Peribronchial Myofibroblastic Tumor (CPMT) after chemotherapy and targeted therapy. The CPMT morphology with <i>EGFR-KDD</i> in the post-therapy specimen might be an evolution induced by the treatment, which suggests the hypothesis that CPMT is part of the morphologic spectrum of infantile fibrosarcoma/cellular mesoblastic nephroma.</p>","PeriodicalId":12700,"journal":{"name":"Genes, Chromosomes & Cancer","volume":"64 4","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gcc.70032","citationCount":"0","resultStr":"{\"title\":\"EGFR-KDD Myofibroblastic Neoplasm or Congenital Peribronchial Myofibroblastic Tumor (CPMT)? Report of a Congenital Myofibroblastic Neoplasm With Unusual Histologic Features\",\"authors\":\"Emma Rullo, Sabina Barresi, Sabrina Rossi, Sara Patrizi, Evelina Miele, Marta Barisella, Michela Casanova, Andrea Ferrari, Stefano Chiaravalli, Gloria Pelizzo, Rita Alaggio\",\"doi\":\"10.1002/gcc.70032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>EGFR-kinase-domain duplication (KDD) has been reported in Infantile fibrosarcoma-like myofibroblastic tumors and cellular mesoblastic nephroma. We report a pulmonary neoplasm with EGFR-(KDD) and infantile fibrosarcoma-like histologic features in a female infant with an unusual clinical and histologic evolution, characterized by persistent disease with morphologic features of Congenital Peribronchial Myofibroblastic Tumor (CPMT) after chemotherapy and targeted therapy. The CPMT morphology with <i>EGFR-KDD</i> in the post-therapy specimen might be an evolution induced by the treatment, which suggests the hypothesis that CPMT is part of the morphologic spectrum of infantile fibrosarcoma/cellular mesoblastic nephroma.</p>\",\"PeriodicalId\":12700,\"journal\":{\"name\":\"Genes, Chromosomes & Cancer\",\"volume\":\"64 4\",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-04-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gcc.70032\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genes, Chromosomes & Cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/gcc.70032\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes, Chromosomes & Cancer","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/gcc.70032","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
EGFR-KDD Myofibroblastic Neoplasm or Congenital Peribronchial Myofibroblastic Tumor (CPMT)? Report of a Congenital Myofibroblastic Neoplasm With Unusual Histologic Features
EGFR-kinase-domain duplication (KDD) has been reported in Infantile fibrosarcoma-like myofibroblastic tumors and cellular mesoblastic nephroma. We report a pulmonary neoplasm with EGFR-(KDD) and infantile fibrosarcoma-like histologic features in a female infant with an unusual clinical and histologic evolution, characterized by persistent disease with morphologic features of Congenital Peribronchial Myofibroblastic Tumor (CPMT) after chemotherapy and targeted therapy. The CPMT morphology with EGFR-KDD in the post-therapy specimen might be an evolution induced by the treatment, which suggests the hypothesis that CPMT is part of the morphologic spectrum of infantile fibrosarcoma/cellular mesoblastic nephroma.
期刊介绍：
Genes, Chromosomes & Cancer will offer rapid publication of original full-length research articles, perspectives, reviews and letters to the editors on genetic analysis as related to the study of neoplasia. The main scope of the journal is to communicate new insights into the etiology and/or pathogenesis of neoplasia, as well as molecular and cellular findings of relevance for the management of cancer patients. While preference will be given to research utilizing analytical and functional approaches, descriptive studies and case reports will also be welcomed when they offer insights regarding basic biological mechanisms or the clinical management of neoplastic disorders.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
