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IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-04-02 DOI:10.1186/s12943-025-02306-w

Muhammad Tufail, Can-Hua Jiang, Ning Li

引用次数: 0

摘要

Wnt 信号通路在发育和组织稳态中起着至关重要的作用，它调节着细胞的增殖、分化和凋亡等关键过程。然而，Wnt 信号通路的异常激活与肿瘤发生、转移和抗药性密切相关，因此成为癌症治疗的重要靶点。这篇综述全面探讨了 Wnt 信号在癌症中的作用，研究了它的正常生理功能、在恶性肿瘤中的失调以及治疗潜力。我们强调了预测 Wnt 信号敏感性的重要性，并确定了各种癌症类型的关键生物标志物。此外，我们还探讨了 Wnt 靶向疗法所面临的挑战和未来前景，包括生物标志物的发现、新兴技术的进步及其在临床实践中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Wnt signaling in cancer: from biomarkers to targeted therapies and clinical translation

The Wnt signaling pathway plays a crucial role in development and tissue homeostasis, regulating key cellular processes such as proliferation, differentiation, and apoptosis. However, its abnormal activation is strongly associated with tumorigenesis, metastasis, and resistance to therapy, making it a vital target for cancer treatment. This review provides a comprehensive insight into the role of Wnt signaling in cancer, examining its normal physiological functions, dysregulation in malignancies, and therapeutic potential. We emphasize the importance of predicting Wnt signaling sensitivity and identify key biomarkers across various cancer types. Additionally, we address the challenges and future prospects of Wnt-targeted therapies, including biomarker discovery, advancements in emerging technologies, and their application in clinical practice.

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.