假体周围关节感染:核心结果集的发展。

IF 4.9 1区 医学 Q1 ORTHOPEDICS
Ian W Kennedy, Fares S Haddad, Matthew P Abdel, Donald S Garbuz, Vanya Gant, R M D Meek, Carsten Perka, Chloe E H Scott, Bryan D Springer, Sam Oussedik, Michael R Whitehouse
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引用次数: 0

摘要

目的:假体周围关节感染(PJI)是关节置换术的严重并发症,具有很高的发病率、死亡率和医疗费用。尽管在诊断和治疗方面取得了进展,但结果报告的不一致阻碍了证据的综合,限制了理解和管理方面的进展。本研究旨在为PJI制定一个核心结局集(COS),以规范文献中的结局报告。方法:采用两阶段改进的德尔菲法,在一系列领域建立共识。第一阶段是由一个国际专家小组确定PJI研究的核心成果。还咨询了患者组,以确保这些领域与患者优先事项相关。第二阶段包括由55名利益相关者组成的更广泛的小组,参与在线共识过程,以最终确定COS。定量和定性数据进行整理,以重新定义整个德尔菲过程的结果。结果:经过改进的两阶段德尔菲过程,所有结果都达到了高度的共识。最终COS包括以下四个领域的23个结果:患者人口统计学和基线特征;感染的特点;手术及治疗详情;结果和后续行动。结论:开发的COS为PJI研究的结果报告提供了一个标准化的框架。通过解决文献中的可变性和不一致性,该COS旨在增强研究之间的可比性,支持可靠的证据合成,并最终指导临床决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Periprosthetic joint infection : development of a core outcome set.

Aims: Periprosthetic joint infection (PJI) is a devastating complication of arthroplasty, with substantial morbidity, mortality, and healthcare costs. Despite advances in diagnosis and treatment, inconsistencies in outcome reporting have hindered evidence synthesis, limiting progress in understanding and management. This study aimed to develop a core outcome set (COS) for PJI to standardize outcome reporting in the literature.

Methods: A two-stage modified Delphi process was conducted to establish consensus across a range of domains. Stage 1 involved the identification of core outcomes in PJI research by an international expert panel. A patient group was also consulted to ensure that the domains were relevant to patient priorities. Stage 2 included a broader group of 55 stakeholders in an online consensus process to finalize the COS. Quantitative and qualitative data were collated to redefine the outcomes throughout the Delphi process.

Results: Following the modified two-stage Delphi process, a high level of consensus was achieved for all outcomes. The final COS included 23 outcomes across the following four domains: patient demographics and baseline characteristics; infection characteristics; surgical and treatment details; and outcomes and follow-up.

Conclusion: The developed COS provides a standardized framework for reporting outcomes in PJI research. By addressing variability and inconsistency in the literature, this COS aims to enhance comparability across studies, support robust evidence synthesis, and ultimately guide clinical decision-making.

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来源期刊
Bone & Joint Journal
Bone & Joint Journal ORTHOPEDICS-SURGERY
CiteScore
9.40
自引率
10.90%
发文量
318
期刊介绍: We welcome original articles from any part of the world. The papers are assessed by members of the Editorial Board and our international panel of expert reviewers, then either accepted for publication or rejected by the Editor. We receive over 2000 submissions each year and accept about 250 for publication, many after revisions recommended by the reviewers, editors or statistical advisers. A decision usually takes between six and eight weeks. Each paper is assessed by two reviewers with a special interest in the subject covered by the paper, and also by members of the editorial team. Controversial papers will be discussed at a full meeting of the Editorial Board. Publication is between four and six months after acceptance.
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