多模态MRI准确识别阿尔茨海默病连续体中不平衡队列中的淀粉样蛋白状态。

IF 3.6 3区 医学 Q2 NEUROSCIENCES
Network Neuroscience Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI:10.1162/netn_a_00423
Giorgio Dolci, Charles A Ellis, Federica Cruciani, Lorenza Brusini, Anees Abrol, Ilaria Boscolo Galazzo, Gloria Menegaz, Vince D Calhoun
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引用次数: 0

摘要

淀粉样蛋白-β (Aβ)斑块与神经原纤维缠结形式的过度磷酸化tau蛋白结合是阿尔茨海默病的两种神经病理学标志。众所周知,Aβ阳性个体的识别可以促进早期诊断。在这项工作中,我们的目标是在不同疾病阶段的不平衡队列中捕获Aβ阳性状态,利用结构、功能和扩散MRI揭示的潜在结构和连通性疾病诱导的调节。值得注意的是,由于队列不平衡,结果可能由这些因素而不是淀粉样蛋白积累指导。每个模态提供的部分视图被整合到模型中,允许在编码Aβ积累效应时充分利用它们的互补性,导致精度为0.762±0.04。通过事后可解释性分析(引导反向传播)评估每种模式带来的信息的特异性,突出潜在的结构和功能变化。值得注意的是,与Aβ沉积相关的生物标志物关键区域可以通过所有模式识别,包括海马、丘脑、楔前叶和扣带回,这证明了该方法的可靠性,以及它在揭示模式特异性可能未知的Aβ沉积特征方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multimodal MRI accurately identifies amyloid status in unbalanced cohorts in Alzheimer's disease continuum.

Amyloid-β (Aβ) plaques in conjunction with hyperphosphorylated tau proteins in the form of neurofibrillary tangles are the two neuropathological hallmarks of Alzheimer's disease. It is well-known that the identification of individuals with Aβ positivity could enable early diagnosis. In this work, we aim at capturing the Aβ positivity status in an unbalanced cohort enclosing subjects at different disease stages, exploiting the underlying structural and connectivity disease-induced modulations as revealed by structural, functional, and diffusion MRI. Of note, due to the unbalanced cohort, the outcomes may be guided by those factors rather than amyloid accumulation. The partial views provided by each modality are integrated in the model, allowing to take full advantage of their complementarity in encoding the effects of the Aβ accumulation, leading to an accuracy of 0.762 ± 0.04. The specificity of the information brought by each modality is assessed by post hoc explainability analysis (guided backpropagation), highlighting the underlying structural and functional changes. Noteworthy, well-established biomarker key regions related to Aβ deposition could be identified by all modalities, including the hippocampus, thalamus, precuneus, and cingulate gyrus, witnessing in favor of the reliability of the method as well as its potential in shedding light on modality-specific possibly unknown Aβ deposition signatures.

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来源期刊
Network Neuroscience
Network Neuroscience NEUROSCIENCES-
CiteScore
6.40
自引率
6.40%
发文量
68
审稿时长
16 weeks
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