IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Reviews in cardiovascular medicine Pub Date : 2025-03-19 eCollection Date: 2025-03-01 DOI:10.31083/RCM26587
Songyan Cai, Qingyuan Dai
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引用次数: 0

摘要

急性心肌梗塞是冠状动脉急性持续缺血缺氧引起的心肌坏死,严重影响公众健康。最近,干细胞研究在治疗心肌梗死方面取得了变革性进展。Notch 信号通路在心肌梗死后的修复过程和心脏再生医学中起着至关重要的作用。此外,Notch 信号通路还可参与调节心肌梗死后的炎症反应、心肌纤维化、氧化应激、心肌细胞凋亡和心肌细胞再生。此外,Notch 信号通路还被应用于心脏组织工程。本综述主要阐述了 Notch 信号通路在心肌梗死修复和心脏再生医学中的研究,旨在为治疗急性心肌梗死提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Advances in Myocardial Infarction Repair and Cardiac Regenerative Medicine via the Notch Signaling Pathway.

Acute myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia in the coronary artery and severely affects public health. Recently, stem cell research has presented transformational developments in treating myocardial infarction. The Notch signaling pathway plays a crucial role in the post-myocardial infarction repair process and cardiac regenerative medicine. Additionally, the Notch signaling pathway can be involved in regulating the inflammatory response, myocardial fibrosis, oxidative stress, cardiomyocyte apoptosis, and cardiomyocyte regeneration after myocardial infarction. Moreover, the Notch signaling pathway is applied in cardiac tissue engineering. This review mainly elaborates on the research on the Notch signaling pathway in repairing myocardial infarction and cardiac regenerative medicine, aiming to provide a reference for treating acute myocardial infarction.

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来源期刊
Reviews in cardiovascular medicine
Reviews in cardiovascular medicine 医学-心血管系统
CiteScore
2.70
自引率
3.70%
发文量
377
审稿时长
1 months
期刊介绍: RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.
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