一种新的全自动OLCR生物计的评估：可重复性，再现性，与SS-OCT生物计的一致性。

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI:10.1007/s40123-025-01120-3

Chak Seng Lei, Xinning Yang, Rui Ning, Jinxuan Xiahou, Xinyu Jiang, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Kexin Li, Jinhai Huang

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引用次数: 0

摘要

本研究旨在评估基于光学低相干反射（OLCR）的新型全自动生物计us -1000 Plus的观察者内重复性和观察者间重复性，以及它与基于扫描源光学相干断层扫描（SS-OCT）的生物计IOLMaster 700的一致性。方法：本前瞻性研究纳入77名健康受试者的77只右眼。测量角膜轴长（AL）、角膜中央厚度（CCT）、水深（AQD）、前房深度（ACD）、最平坦、最陡、平均角膜度数（Kf、Ks、Km）、散光星等（AST）、J0、J45矢量和角膜直径（CD）。采用受试者内标准差（Sw）、重测重复性（TRT）、变异系数（CoV）和类内相关系数（ICC）评价重复性和再现性。为了比较不同设备之间的差异并建立一致性，使用配对t检验和Bland-Altman图。采用双角图分析角膜散光。结果：重复性和再现性分析显示，所有评估参数的Sw、TRT和CoV均较低，同时ICC值较高。掐间协议好,Bland-Altman情节显示狭窄95%协议(贷款)的极限(AL - 0.05到0.04毫米,有条件现金援助- 22.03 - 7.50μm, AQD 0.01到0.14毫米,ACD 0.00到0.13毫米,LT - 0.16到0.02毫米,Kf - 0.24 - 0.23 D, Ks - 0.36 - 0.21 D,公里,0.24 - 0.16 D, AST - 0.41 - 0.27 D j₀- 0.15 - 0.17 D, J45 - 0.14 - 0.22 D, CD - 0.38到0.18毫米)。结论：LUS-1000 Plus具有较高的重复性和再现性，与IOLMaster 700具有良好的一致性，证实了其在临床实践中的可靠性和与IOLMaster 700的互换性。

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Evaluation of a New Fully Automatic OLCR Biometer: Repeatability, Reproducibility, and Agreement with an SS-OCT Biometer.

Introduction: This study aimed to evaluate the intraobserver repeatability and interobserver reproducibility of the LUS-1000 Plus, a new fully automatic optical low coherence reflectometry (OLCR)-based biometer, and its agreement with the IOLMaster 700, a swept-source optical coherence tomography (SS-OCT)-based biometer, for biometric measurement.

Methods: This prospective study included 77 right eyes from 77 healthy participants. The axial length (AL), central corneal thickness (CCT), aqueous depth (AQD), anterior chamber depth (ACD), flattest, steepest, mean keratometry (Kf, Ks, Km), astigmatism magnitude (AST), J₀, J₄₅ vectors, and corneal diameter (CD) were measured. Repeatability and reproducibility were evaluated using the within-subject standard deviation (S_w), test-retest (TRT) repeatability, coefficient of variation (CoV), and intraclass correlation coefficient (ICC). To compare differences and establish agreement between the devices, paired t test and Bland-Altman plots were utilized. Double-angle plots were employed to analyze corneal astigmatism.

Results: Repeatability and reproducibility analysis revealed low S_w, TRT, and CoV, accompanied by high ICC values for all evaluated parameters. The interdevice agreement was excellent, Bland-Altman plots showed narrow 95% limits of agreement (LoA) (AL - 0.05 to 0.04 mm, CCT - 22.03 to - 7.50 μm, AQD 0.01 to 0.14 mm, ACD 0.00 to 0.13 mm, LT - 0.16 to 0.02 mm, Kf - 0.24 to 0.23 D, Ks - 0.36 to 0.21 D, Km - 0.24 to 0.16 D, AST - 0.41 to 0.27 D, J₀ - 0.15 to 0.17 D, J₄₅ - 0.14 to 0.22 D, CD - 0.38 to 0.18 mm).

Conclusion: The LUS-1000 Plus demonstrated high repeatability and reproducibility, and excellent agreement with the IOLMaster 700, confirming its reliability and interchangeable use with the IOLMaster 700 in clinical practice.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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