角膜共聚焦显微镜可识别格林-巴罗综合征患者的角膜神经丧失。

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Muscle & Nerve Pub Date : 2025-04-01 DOI:10.1002/mus.28408

Adnan Khan, Mohammed Alhatou, Liaquat Ali, Gholam Adeli, Georgios Ponirakis, Hoda Gad, Abeer Sabry Safan, Rashaa K M Aldabbagh, Ioannis N Petropoulos, Ali Alsalahat, Rayaz A Malik

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引用次数: 0

摘要

简介/目的：吉兰-巴罗综合征（GBS）患者通常表现为感觉丧失和虚弱，但他们也可能有神经性疼痛、热阈值升高和表皮内神经纤维丢失。本研究的主要目的是评估GBS患者小神经纤维损伤的证据。方法：9例GBS患者和15例年龄匹配的健康对照者采用CCM定量测定角膜神经纤维密度（CNFD）、角膜神经纤维长度（CNFL）和角膜神经分支密度（CNBD），采用双神经病变指数（DN4）评估神经性疼痛、皮肤电导（ESC）、振动感知阈值（VPT）和神经传导研究。结果：GBS患者的CNFD （p = 0.008）、CNFL （p = 0.011）、CNBD （p = 0.005）、手上的ESC （p = 0.024）和脚上的ESC （p = 0.046）较健康对照组低，而DN4 （p = 0.007）较高。讨论：GBS患者有小神经纤维损伤的证据，如角膜神经纤维丢失、神经性疼痛和sudomotor功能障碍。CCM可能增加了评估GBS患者小神经纤维受累的工具箱。

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Corneal Confocal Microscopy Identifies Corneal Nerve Loss in Patients With Guillain-Barré Syndrome.

Introduction/aims: Patients with Guillain-Barré syndrome (GBS) commonly present with sensory loss and weakness, but they may also have neuropathic pain, elevated thermal thresholds, and intraepidermal nerve fiber loss. The primary aim of this study was to assess for evidence of small nerve fiber damage in patients with GBS. METHODS: Nine patients with GBS and 15 age-matched healthy controls underwent CCM to quantify corneal nerve fiber density (CNFD), corneal nerve fiber length (CNFL), and corneal nerve branch density (CNBD), Douleur Neuropathique en 4 (DN4) to assess neuropathic pain, electrochemical skin conductance (ESC), vibration perception threshold (VPT), and nerve conduction studies.

Results: CNFD (p = 0.008), CNFL (p = 0.011), CNBD (p = 0.005), and ESC on the hands (p = 0.024) and the feet (p = 0.046) were lower, whereas DN4 (p = 0.007) was higher in patients with GBS compared to healthy controls.

Discussion: Patients with GBS have evidence of small nerve fiber damage as evidenced by corneal nerve fiber loss, neuropathic pain, and sudomotor dysfunction. CCM may add to the toolbox for the evaluation of small nerve fiber involvement in patients with GBS.

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来源期刊

Muscle & Nerve 医学-临床神经学

CiteScore

6.40

自引率

5.90%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.