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IF 1.4 4区医学 Q3 SURGERY

Annals of Plastic Surgery Pub Date : 2025-04-01 DOI:10.1097/SAP.0000000000004267

Nancy Qin, Makayla Kochheiser, Izzet Akosman, David Dugue, Alex Raghunandan, Chetan Pavuluri, Carson Gundlach, Anna M Vaeth, Lucy Wei, Benjamin R Wesorick, David M Otterburn

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引用次数: 0

摘要

背景：富血小板血浆（PRP）和富血小板纤维蛋白（PRF富血小板血浆（PRP）和富血小板纤维蛋白（PRF）利用生长因子刺激天然组织修复和再生，是很有前景的面部年轻化治疗方法。尽管它们越来越受欢迎，但其有效性仍存在争议，研究结果不一。本系统性综述评估了目前有关 PRP/PRF 疗法的证据及其对以下 6 个面部衰老关键参数的影响：皱纹、纹理、色素沉着、弹性、皮肤厚度和水合作用：在 PubMed、Embase 和 Cochrane 数据库中对 2010 年以后发表的对照试验、前瞻性队列研究和系列病例进行了全面的文献检索。符合条件的研究包括 5 名以上的患者，对 PRP 或 PRF 作为单一疗法进行了评估，并至少涉及了所列 6 项面部衰老参数中的一项。文章由两名独立研究人员进行筛选，并采用牛津循证医学中心的分级标准对证据质量进行评分：共有 20 篇文章符合纳入标准，其中包括 514 名患者。其中 16 项研究将 PRP/PRF 与对照组或基线进行了比较，4 项研究将 PRP/PRF 与其他治疗方法进行了比较。皱纹和细纹（16 例）是最常见的研究参数，其次是色素沉着（12 例）、肤质（11 例）、弹性（6 例）、皮肤厚度（5 例）和水合作用（4 例）。80%的研究报告称 PRP/PRF 治疗后皮肤厚度有明显改善，75%的研究报告称皮肤弹性有明显改善，40%的研究报告称皮肤皱纹有明显改善，33%的研究报告称皮肤纹理有明显改善，17%的研究报告称皮肤色素沉着有明显改善，0%的研究报告称皮肤水合作用有明显改善。报告皮肤色泽不良的研究比例最高（41.7%），而报告皮肤水合无改善的研究比例最高（67%）。此外，所有对患者满意度进行评估的研究都报告称，从治疗前到治疗后，患者的满意度都有显著提高。所有纳入的研究均未报告严重不良事件：本系统综述发现，皮肤厚度和弹性是 PRP/PRF 治疗后改善效果最强的面部衰老参数，而皮肤水合作用则最弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Systematic Review of Platelet-Rich Plasma and Platelet-Rich Fibrin in Facial Rejuvenation.

Background: Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are promising treatments for facial rejuvenation, leveraging growth factors to stimulate natural tissue repair and regeneration. Despite their growing popularity, their effectiveness remains controversial, with studies yielding mixed results. This systematic review evaluates the current evidence on PRP/PRF therapies and their effect on the following 6 key parameters of facial aging: wrinkles, texture, dyschromia, elasticity, skin thickness, and hydration.

Methods: A comprehensive literature search was performed in PubMed, Embase, and Cochrane databases for controlled trials, prospective cohort studies, and case series published after 2010. Eligible studies included more than 5 patients, evaluated PRP or PRF as monotherapy, and addressed at least 1 of the 6 listed parameters of facial aging. Articles were screened by 2 independent investigators and scored for quality of evidence using the Oxford Centre for Evidence-Based Medicine hierarchy.

Results: Twenty articles, comprising 514 patients, met inclusion criteria. Sixteen studies compared PRP/PRF to a control or baseline, while 4 compared them to alternative treatments. Wrinkles and fine lines (n = 16) were the most frequently studied parameters, followed by dyschromia (n = 12), texture (n = 11), elasticity (n = 6), skin thickness (n = 5), and hydration (n = 4). Significant improvements following PRP/PRF treatment were reported in 80% of studies on skin thickness, 75% on elasticity, 40% on wrinkles, 33% on texture, 17% on dyschromia, and 0% on hydration. Skin dyschromia had the highest proportion of studies reporting mixed findings (41.7%), whereas skin hydration had the highest proportion of studies reporting no improvement (67%). Additionally, all studies evaluating patient satisfaction reported significant improvements from pretreatment to posttreatment. No serious adverse events were reported in any of the included studies.

Conclusions: This systematic review identified skin thickness and elasticity as the facial aging parameters with the strongest evidence of improvement following PRP/PRF treatment, while skin hydration showed the weakest.

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来源期刊

Annals of Plastic Surgery 医学-外科

CiteScore

2.70

自引率

13.30%

发文量

584

审稿时长

6 months

期刊介绍： The only independent journal devoted to general plastic and reconstructive surgery, Annals of Plastic Surgery serves as a forum for current scientific and clinical advances in the field and a sounding board for ideas and perspectives on its future. The journal publishes peer-reviewed original articles, brief communications, case reports, and notes in all areas of interest to the practicing plastic surgeon. There are also historical and current reviews, descriptions of surgical technique, and lively editorials and letters to the editor.