先天性膈疝中隐睾的危险因素：日本的一项多中心研究。

IF 2.4 2区医学 Q1 PEDIATRICS

Journal of pediatric surgery Pub Date : 2025-03-27 DOI:10.1016/j.jpedsurg.2025.162297

Satoshi Umeda , Noriaki Usui , Kouji Nagata , Hiroomi Okuyama , Yoshiaki Sato , Hidehiko Maruyama , Kouji Masumoto , Yuta Yazaki , Tadaharu Okazaki , Yunosuke Kawaguchi , Katsuaki Toyoshima , Masaya Yamoto , Kiyokazu Kim , Noboru Inamura , Yuhki Koike , Akiko Yokoi , Keita Terui

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引用次数: 0

摘要

背景：本研究旨在探讨先天性膈疝（CDH）中隐睾（UDT）的发生率及发生UDT的临床危险因素。方法：使用日本CDH研究组的数据库，回顾性评估2006年至2021年出生的CDH男性患者的UDT。通过比较有UDT和没有UDT的患者来检查UDT的危险因素。结果：605名患有CDH的男孩中，408名被随访至少一年，并被纳入本研究。408例患者中有50例（12.3%）接受了UDT治疗，41例（10.2%）患者接受了兰花固定术。同侧发生UDT 24例，对侧发生UDT 6例；其余20例为双侧UDT。UDT患者与未UDT患者的比较显示，UDT患者的出生体重明显降低，Apgar评分明显降低。此外，UDT患者表现出明显更高的非孤立性、“肝脏上升”、C/D型缺损和补片闭合率。多因素分析显示，C/D型缺损是发生UDT的独立危险因素。结论：男孩CDH的UDT发生率和对睾丸切除术的需求增加。在CDH患者中，UDT可能倾向于发生在受CDH影响的同侧。尽管不同的因素被认为与睾丸下降有关，但膈大缺损被认为是CDH中UDT的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Risk Factors of Undescended Testis in Congenital Diaphragmatic Hernia: A Multicenter Study in Japan

Background

This study aimed to examine the incidence of undescended testis (UDT) in congenital diaphragmatic hernia (CDH) and clinical risk factors for developing UDT.

Methods

Male patients with CDH born between 2006 and 2021 were retrospectively assessed for UDT using the database of the Japanese CDH study group. The UDT risk factors were examined by comparing patients with and without UDT.

Results

Of the 605 boys with CDH, 408 were followed for at least one year and were included in this study. A total of 50 (12.3 %) of the 408 patients experienced UDT and orchidopexy was performed in 41 (10.2 %) patients. Twenty-four cases developed UDT on the same side of CDH, whereas only 6 cases developed UDT on the contralateral side of CDH; the remaining 20 cases were bilateral UDT. Comparison between the patients with and without UDT revealed significantly lower birth weight and lower Apgar Score in the patients with UDT. Furthermore, patients with UDT demonstrated a significantly higher rate of non-isolated, “liver-up”, defect with C/D type, and patch closure. Multivariate analysis showed that the C/D type defect was deemed an independent risk factor for developing UDT.

Conclusions

The incidence of UDT and the need for orchidopexy are elevated in boys with CDH. In patients with CDH, UDT may tend to occur on the same side as that affected by CDH. The diaphragmatic large defect was considered to be an independent risk factor for UDT in CDH although different factors are thought to be involved in testicular descent.

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来源期刊

Journal of pediatric surgery 医学-外科

CiteScore

1.10

自引率

12.50%

发文量

569

审稿时长

38 days

期刊介绍： The journal presents original contributions as well as a complete international abstracts section and other special departments to provide the most current source of information and references in pediatric surgery. The journal is based on the need to improve the surgical care of infants and children, not only through advances in physiology, pathology and surgical techniques, but also by attention to the unique emotional and physical needs of the young patient.