tDCS和tACS对帕金森病脑振荡和运动症状的共同和特异性影响。

IF 11.7 1区医学 Q1 CELL BIOLOGY

Cell Reports Medicine Pub Date : 2025-03-25 DOI:10.1016/j.xcrm.2025.102044

Jiafang Liu, Ying Zhu, Biao Chen, Qiujian Meng, Panpan Hu, Xianwen Chen, Junjie Bu

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引用次数: 0

摘要

帕金森氏症（PD）导致神经变性和异常的大脑振荡，引起运动功能障碍。经颅刺激（经颅直流电刺激[tDCS]/经颅交流电刺激[tACS]）可缓解症状，但其振荡调节机制尚不清楚。本随机对照试验（RCT）研究了60例PD患者单次tDCS/tACS的效果，这些患者被分为tDCS、tACS （20 Hz）组和假手术组。每个人在执行简单的反应任务时接受20分钟的左运动皮层刺激。开源静息状态脑电图（EEG）数据显示PD患者θ波功率增加，β波功率下降。在RCT中，tDCS和tACS增强β功率，改善僵硬和运动迟缓。此外，tDCS可降低θ波功率，特别是减轻震颤症状。值得注意的是，θ / β比值比单独的θ功率更有效地预测和调节tDCS引起的震颤变化。本研究揭示了tDCS广泛调节振荡，改善多种症状，而tACS针对单一振荡缓解特定症状，强调了多种振荡在PD运动病理生理中的重要作用。本研究已在ClinicalTrials.gov注册（NCT05678725）。

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Common and specific effects in brain oscillations and motor symptoms of tDCS and tACS in Parkinson's disease.

Parkinson's disease (PD) leads to neurodegeneration and abnormal brain oscillations, causing motor dysfunction. Transcranial stimulation (transcranial direct current stimulation [tDCS]/transcranial alternating current stimulation [tACS]) may alleviate symptoms, but their oscillatory modulation mechanisms remain unclear. This randomized controlled trial (RCT) examines the effects of single-session tDCS/tACS on 60 PD patients, assigned to tDCS, tACS (20 Hz), or sham groups. Each receives 20-min left motor cortex stimulation while performing a simple reaction task. Open-source resting-state electroencephalogram (EEG) data reveal increased theta and decreased beta power in PD. In the RCT, tDCS and tACS enhance beta power, improving rigidity and bradykinesia. Additionally, tDCS reduces theta power, specifically alleviating tremor symptoms. Notably, the theta/beta ratio predicts and mediates tremor changes induced by tDCS more effectively than theta power alone. This sutdy revealed that tDCS broadly modulates oscillations, improving multiple symptoms, while tACS targets a single oscillation for specific symptom relief, emphasizing the crucial role of diverse oscillations in PD motor pathophysiology. This study was registered at ClinicalTrials.gov (NCT05678725).

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来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.