含1,4-苯并二氧环片段的1,3,4-恶二唑衍生物的合成及其抗心律失常活性

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-03-31 DOI:10.1134/S1070428024602966

A. S. Avagyan, S. O. Vardanyan, A. B. Sargsyan, H. A. Panosyan, G. S. Mkrtchyan, H. E. Tumajyan, R. E. Muradyan, A. A. Aghekyan

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引用次数: 0

摘要

先前报道的4-（1,4-苯二氮杂-6-基）四氢- 2h -吡喃-4-羰基氯与水合肼反应生成对称的二酰基肼，该二酰肼在氯磷的作用下被环化为2,5-二[4-（1,4-苯二氮杂-6-基）四氢- 2h -吡喃-4-基]-1,3,4-恶二唑。以4-（1,4-苯并二氮杂-6-基）-四氢- 2h -吡喃-4-羰基氯与各种酸性酰肼缩合为原料合成了不对称的2,5-二取代1,3,4-恶二唑，然后再与磷酸酰氯环化。对合成的化合物进行抗心律失常活性评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment

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Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment

The reaction of previously reported 4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carbonyl chloride with hydrazine hydrate gave symmetrical diacylhydrazine which was cyclized to 2,5-bis[4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-yl]-1,3,4-oxadiazole by the action of phosphoryl chloride. Unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles were synthesized by the condensation of 4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carbonyl chloride with various acid hydrazides, followed by cyclization of the resulting diacylhydrazines with phosphoryl chloride. The synthesized compounds were evaluated for their antiarrhythmic activity.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.