米索前列醇(9 e)肟

IF 0.9 4区 化学 Q4 CHEMISTRY, ORGANIC
N. K. Selezneva, V. V. Zagitov, N. S. Vostrikov, A. M. Gimazetdinov, M. S. Miftakhov
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引用次数: 0

摘要

为了寻找新的化学性质更稳定的类似物(前药),合成了米索前列醇(9E/Z)-肟类异构体和单个11α-乙酰氧基(9E)- o -乙酰氧肟衍生物并对其进行了表征。根据1H NMR谱中肟的OH信号强度,估计E和Z肟的比值为10:1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Misoprostol (9E)-Oxime

Misoprostol (9E)-Oxime

With the goal of searching for new more chemically stable analogues (prodrugs), isomeric misoprostol (9E/Z)-oximes and individual 11α-acetoxy (9E)-O-acetyloxime derivative have been synthesized and characterized. The ratio of the E and Z oximes has been estimated at 10:1 on the basis of the oxime OH signal intensities in the 1H NMR spectrum.

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来源期刊
CiteScore
1.40
自引率
25.00%
发文量
139
审稿时长
3-6 weeks
期刊介绍: Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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