Fe（III）催化1,6-炔型Ugi - 4-CR加合物自由基环化立体选择性合成α-烯基-γ-内酰胺

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-31 DOI:10.1021/acs.orglett.5c00544

Silvia J. Becerra-Anaya, Luis A. Polindara-García

引用次数: 0

摘要

通过Fe（III）催化1,6-炔型Ugi - 4-CR加合物的5-外显环化，合成了一种新型的高立体选择性α-烯基-γ-内酰胺。该方法在温和的条件下操作，反应时间短，能够有效地构建这些有价值的支架，同时表现出广泛的底物相容性和良好的产率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Fe(III)-Catalyzed Stereoselective Synthesis of α-Alkenyl-γ-lactams via Radical Cyclization of 1,6-Enyne-Type Ugi 4-CR Adducts

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Fe(III)-Catalyzed Stereoselective Synthesis of α-Alkenyl-γ-lactams via Radical Cyclization of 1,6-Enyne-Type Ugi 4-CR Adducts

A novel and highly stereoselective synthesis of α-alkenyl-γ-lactams via an Fe(III)-catalyzed radical 5-exo-dig cyclization of 1,6-enyne-type Ugi 4-CR adducts is described. This method operates under mild conditions and requires short reaction times, enabling the efficient construction of these valuable scaffolds while demonstrating broad substrate compatibility and good yields.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.