Menin:从分子洞察到临床影响。

IF 3 4区 医学 Q2 GENETICS & HEREDITY
Margaret R Brown, Yadira M Soto-Feliciano
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引用次数: 0

摘要

Menin是MEN1基因的蛋白质产物,对发育至关重要,并与多种不同类型的癌症有关。这些包括白血病和几种不同的实体瘤,包括神经内分泌肿瘤。Menin以上下文依赖的方式与许多不同的蛋白质伴侣和基因组位点相互作用,暗示它参与许多细胞过程。Menin的作用也因肿瘤类型而异,在一些组织中作为肿瘤抑制因子,在另一些组织中作为致癌辅助因子。鉴于Menin在癌症中的作用,特别是其在急性髓性白血病中的致癌作用,Menin抑制剂的开发在过去10-15年中一直在扩大。许多抑制剂已经在临床试验中,其中一种最近获得了美国食品和药物管理局(FDA)的批准。本文就Menin在多种肿瘤中的作用、Menin抑制剂的研究进展及临床应用等方面进行综述,并就Menin抑制剂在未来5-10年内应重点关注的领域进行探讨,以扩大Menin抑制剂的使用和疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Menin: from molecular insights to clinical impact.

Menin, the protein product of the MEN1 gene, is essential for development and has been implicated in multiple different cancer types. These include leukemias and several different solid tumors, including neuroendocrine tumors. Menin interacts with many different protein partners and genomic loci in a context-dependent manner, implicating it in numerous cellular processes. The role of Menin varies across tumor types as well, acting as a tumor suppressor in some tissues and an oncogenic co-factor in others. Given the role of Menin in cancer, and particularly its oncogenic role in acute myeloid leukemia, the development of Menin inhibitors has been an expanding field over the past 10-15 years. Many inhibitors have been in clinical trials and one has recently received approval from the Food and Drug Administration (FDA). In this review, we explore the role of Menin in multiple cancer types, the development of Menin inhibitors and their clinical applications and what the focus of the field should be in the next 5-10 years to expand the use and efficacy of these drugs.

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来源期刊
Epigenomics
Epigenomics GENETICS & HEREDITY-
CiteScore
5.80
自引率
2.60%
发文量
95
审稿时长
>12 weeks
期刊介绍: Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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