利用离体生物力学模型设计和评估瓣膜干预:斯坦福大学的经验。

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Gabe Weininger, Stefan Elde, Yuanjia Zhu, Y Joseph Woo
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引用次数: 0

摘要

随着人口老龄化,瓣膜性心脏病患病率的增加,人们越来越重视持久的瓣膜修复策略。尽管瓣膜治疗取得了许多进展,但对现有修复策略的严格生物力学评估和验证很少。我们的研究小组设计了一种新颖的3d打印离体心脏模拟器,这使我们能够改进和创新许多手术修复策略,并在移植的动物心脏瓣膜上实时提供血液动力学和生物力学反馈。从这种新型模拟器获得的数据直接影响了我们机构的临床实践。它也被证明是一个优秀的平台,为瓣膜装置的发展。在此,我们将回顾体外生物力学模拟的经验,并将其细分为主动脉瓣病理、二尖瓣病理和新型装置的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Design and evaluation of valve interventions using ex vivo biomechanical modeling: the Stanford experience.

The increase in prevalence of valvular heart disease coupled with an aging population has placed increased emphasis on durable valvular repair strategies. Despite many advances in valvular therapies, there has been little rigorous biomechanical evaluation and validation of existing repair strategies. Our research group engineered a novel 3D-printed, ex vivo heart simulator, which has allowed us to refine and innovate numerous surgical repair strategies with hemodynamic and biomechanical feedback in real time on explanted animal heart valves. Data obtained from this novel simulator have directly influenced clinical practice at our institution. It has also proven to be an outstanding platform for valvular device development. Herein, we will review our experience with ex vivo biomechanical simulation, subdivided into work on aortic valve pathology, mitral valve pathology, and novel devices.

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来源期刊
General Thoracic and Cardiovascular Surgery
General Thoracic and Cardiovascular Surgery Medicine-Pulmonary and Respiratory Medicine
CiteScore
2.70
自引率
8.30%
发文量
142
期刊介绍: The General Thoracic and Cardiovascular Surgery is the official publication of The Japanese Association for Thoracic Surgery and The Japanese Association for Chest Surgery, the affiliated journal of The Japanese Society for Cardiovascular Surgery, that publishes clinical and experimental studies in fields related to thoracic and cardiovascular surgery.
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