妊娠前体重增加与妊娠糖尿病风险增加有关

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Sunmie Kim, Kyungdo Han, Su-Yeon Choi, Min Joo Kim, Sun Young Yang, Seung Ho Choi, Jeong Yoon Yim, Jin Ju Kim, Min-Jeong Kim
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引用次数: 0

摘要

背景:研究报道了在不同人群中妊娠前体重增加与妊娠期糖尿病(GDM)的后续发展之间的显著关联。目前的研究旨在利用韩国国民健康保险服务数据库中的数据来调查这种关系。方法:我们进行了一项基于全国人群的回顾性队列研究,涉及159798名在2015年至2017年期间分娩的妇女,并在各自估计受孕日期前1年(指标检查)和3年(基线检查)进行了两次国家健康筛查。参与者根据两次检查之间的体重变化程度分为五组:超过10%,5%至10%,-5%至5%(参照组),-10%至-5%和超过-10%。该研究评估了孕前体重变化与GDM风险之间的关系。结果:在分析的146363名女性中,11012名(7.52%)被诊断为GDM。多元回归分析显示,体重增加5%至10%的女性患GDM的风险增加12%(调整优势比[aOR], 1.12;95%可信区间[CI], 1.06 ~ 1.17),而增加≥10%的患者风险增加34% (aOR, 1.34;95% CI, 1.26 ~ 1.43)。值得注意的是,在指数检查中,非肥胖或非代谢综合征组妊娠前体重增加与GDM风险特别相关。结论:妊娠前体重增加与GDM的高风险呈剂量依赖关系。这种关联在非肥胖个体中更为明显,这强调了减少孕前体重增加对预防GDM的重要性,即使在非肥胖女性中也是如此。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pregravid Weight Gain Is Associated with an Increased Risk of Gestational Diabetes.

Background: Studies have reported a significant association between pregravid weight gain and the subsequent development of gestational diabetes mellitus (GDM) in various populations. The current study aims to investigate this relationship using data from the Korean National Health Insurance Service database.

Methods: We conducted a retrospective nationwide population-based cohort study, involving 159,798 women who gave birth between 2015 and 2017 and had undergone two national health screening examinations: 1 year (index checkup) and 3 years before (baseline checkup) their respective estimated conception date. Participants were categorized into five groups based on the extent of weight change between the two examinations: more than 10%, 5% to 10%, -5% to 5% (reference group), -10% to -5%, and more than -10%. The study assessed the association between pregravid weight change and GDM risk.

Results: Among the 146,363 women analyzed, 11,012 (7.52%) were diagnosed with GDM. Multiple regression analysis revealed that women who gained 5% to 10% of their weight had a 12% increased risk of GDM (adjusted odds ratio [aOR], 1.12; 95% confidence interval [CI], 1.06 to 1.17), while those who gained ≥10% had a 34% higher risk (aOR, 1.34; 95% CI, 1.26 to 1.43). Notably, pregravid weight gain was particularly associated with GDM risk in non-obese or non-metabolic syndrome groups at index checkup.

Conclusion: Pregravid weight gain showed a dose-dependent association with a higher risk of GDM. This association was more pronounced in non-obese individuals emphasizing the importance of minimizing pregravid weight gain for GDM prevention, even in non-obese women.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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