未经治疗的晚期非小细胞肺癌患者化疗前运动状态的恶化作为预后因素

Q3 Medicine

Cancer treatment and research communications Pub Date : 2025-01-01 DOI:10.1016/j.ctarc.2025.100915

Kenju Ando, Hirotsugu Kenmotsu, Yuichiro Nishibori, Akiko Tamura, Suguru Matsuda, Meiko Morita, Motoki Sekikawa, Kosei Doshita, Keita Miura, Hiroaki Kodama, Michitoshi Yabe, Noboru Morikawa, Yuko Iida, Nobuaki Mamesaya, Haruki Kobayashi, Ryo Ko, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, Toshiaki Takahashi

{"title":"未经治疗的晚期非小细胞肺癌患者化疗前运动状态的恶化作为预后因素","authors":"Kenju Ando, Hirotsugu Kenmotsu, Yuichiro Nishibori, Akiko Tamura, Suguru Matsuda, Meiko Morita, Motoki Sekikawa, Kosei Doshita, Keita Miura, Hiroaki Kodama, Michitoshi Yabe, Noboru Morikawa, Yuko Iida, Nobuaki Mamesaya, Haruki Kobayashi, Ryo Ko, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, Toshiaki Takahashi","doi":"10.1016/j.ctarc.2025.100915","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>The prognostic impact of changes in performance status (PS) of untreated patients with advanced non-small cell lung cancer (NSCLC) are not clear. This study aimed to evaluate the prognostic impact of acute PS deterioration in patients with untreated advanced NSCLC.</div></div><div><h3>Methods</h3><div>This study is a single center, retrospective, observational study. Patients with Stage IV NSCLC who were referred to our institution between January 2018 and March 2023 were retrospectively reviewed. Patients were divided into three groups: 1) patients with PS 0 or 1 at referral and the start of chemotherapy; 2) patients with PS 2 or worse at initial referral and the start of chemotherapy; and 3) patients with PS 0 or 1 at referral that deteriorated to PS 2 or worse at the start of chemotherapy. The prognoses of Groups 2 and 3 were compared with those of Group 1.</div></div><div><h3>Results</h3><div>A total of 373 patients were included: 321 in Group 1, 20 in Group 2, and 32 in Group 3. The median overall survival (OS) of Group 3 was shorter than that of Group 1 (9.3 vs. 27.1 months, hazard ratio [HR] 2.56, <em>p</em> < 0.01). The median OS of Group 2 was also shorter than that of Group 1, although not as significant as in Group 3 (20.2 vs. 27.1 months, HR 1.68, <em>p</em> = 0.06). After adjusting for symptoms, liver and pericardial metastases were associated with PS deterioration in multivariate analysis.</div></div><div><h3>Conclusion</h3><div>Among patients with untreated advanced NSCLC, acute PS deterioration before chemotherapy administration was associated with poor prognosis.</div></div>","PeriodicalId":9507,"journal":{"name":"Cancer treatment and research communications","volume":"43 ","pages":"Article 100915"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Deterioration of performance status before administration of chemotherapy as a prognostic factor in untreated advanced non-small cell lung cancer\",\"authors\":\"Kenju Ando, Hirotsugu Kenmotsu, Yuichiro Nishibori, Akiko Tamura, Suguru Matsuda, Meiko Morita, Motoki Sekikawa, Kosei Doshita, Keita Miura, Hiroaki Kodama, Michitoshi Yabe, Noboru Morikawa, Yuko Iida, Nobuaki Mamesaya, Haruki Kobayashi, Ryo Ko, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, Toshiaki Takahashi\",\"doi\":\"10.1016/j.ctarc.2025.100915\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>The prognostic impact of changes in performance status (PS) of untreated patients with advanced non-small cell lung cancer (NSCLC) are not clear. This study aimed to evaluate the prognostic impact of acute PS deterioration in patients with untreated advanced NSCLC.</div></div><div><h3>Methods</h3><div>This study is a single center, retrospective, observational study. Patients with Stage IV NSCLC who were referred to our institution between January 2018 and March 2023 were retrospectively reviewed. Patients were divided into three groups: 1) patients with PS 0 or 1 at referral and the start of chemotherapy; 2) patients with PS 2 or worse at initial referral and the start of chemotherapy; and 3) patients with PS 0 or 1 at referral that deteriorated to PS 2 or worse at the start of chemotherapy. The prognoses of Groups 2 and 3 were compared with those of Group 1.</div></div><div><h3>Results</h3><div>A total of 373 patients were included: 321 in Group 1, 20 in Group 2, and 32 in Group 3. The median overall survival (OS) of Group 3 was shorter than that of Group 1 (9.3 vs. 27.1 months, hazard ratio [HR] 2.56, <em>p</em> < 0.01). The median OS of Group 2 was also shorter than that of Group 1, although not as significant as in Group 3 (20.2 vs. 27.1 months, HR 1.68, <em>p</em> = 0.06). After adjusting for symptoms, liver and pericardial metastases were associated with PS deterioration in multivariate analysis.</div></div><div><h3>Conclusion</h3><div>Among patients with untreated advanced NSCLC, acute PS deterioration before chemotherapy administration was associated with poor prognosis.</div></div>\",\"PeriodicalId\":9507,\"journal\":{\"name\":\"Cancer treatment and research communications\",\"volume\":\"43 \",\"pages\":\"Article 100915\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer treatment and research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468294225000528\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer treatment and research communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468294225000528","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

未经治疗的晚期非小细胞肺癌（NSCLC）患者表现状态（PS）变化对预后的影响尚不清楚。本研究旨在评估未经治疗的晚期NSCLC患者急性PS恶化对预后的影响。方法本研究为单中心、回顾性、观察性研究。回顾性分析了2018年1月至2023年3月期间转介至我们机构的IV期NSCLC患者。患者分为三组：1)转诊和化疗开始时PS为0或1的患者；2)首次转诊及化疗开始时ps2及以上的患者；3)转诊时ps0或1，化疗开始时恶化为ps2或更糟的患者。比较2、3组与1组的预后。结果共纳入373例患者：1组321例，2组20例，3组32例。3组的中位总生存期（OS）短于1组(9.3个月vs. 27.1个月，风险比[HR] 2.56, p <；0.01)。2组的中位OS也短于1组，但不如3组显著（20.2个月vs. 27.1个月，HR 1.68, p = 0.06）。在调整症状后，在多变量分析中肝脏和心包转移与PS恶化相关。结论在未经治疗的晚期NSCLC患者中，化疗前急性PS恶化与预后不良相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Deterioration of performance status before administration of chemotherapy as a prognostic factor in untreated advanced non-small cell lung cancer

Introduction

The prognostic impact of changes in performance status (PS) of untreated patients with advanced non-small cell lung cancer (NSCLC) are not clear. This study aimed to evaluate the prognostic impact of acute PS deterioration in patients with untreated advanced NSCLC.

Methods

This study is a single center, retrospective, observational study. Patients with Stage IV NSCLC who were referred to our institution between January 2018 and March 2023 were retrospectively reviewed. Patients were divided into three groups: 1) patients with PS 0 or 1 at referral and the start of chemotherapy; 2) patients with PS 2 or worse at initial referral and the start of chemotherapy; and 3) patients with PS 0 or 1 at referral that deteriorated to PS 2 or worse at the start of chemotherapy. The prognoses of Groups 2 and 3 were compared with those of Group 1.

Results

A total of 373 patients were included: 321 in Group 1, 20 in Group 2, and 32 in Group 3. The median overall survival (OS) of Group 3 was shorter than that of Group 1 (9.3 vs. 27.1 months, hazard ratio [HR] 2.56, p < 0.01). The median OS of Group 2 was also shorter than that of Group 1, although not as significant as in Group 3 (20.2 vs. 27.1 months, HR 1.68, p = 0.06). After adjusting for symptoms, liver and pericardial metastases were associated with PS deterioration in multivariate analysis.

Conclusion

Among patients with untreated advanced NSCLC, acute PS deterioration before chemotherapy administration was associated with poor prognosis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cancer treatment and research communications Medicine-Oncology

CiteScore

4.30

自引率

0.00%

发文量

148

审稿时长

56 days

期刊介绍： Cancer Treatment and Research Communications is an international peer-reviewed publication dedicated to providing comprehensive basic, translational, and clinical oncology research. The journal is devoted to articles on detection, diagnosis, prevention, policy, and treatment of cancer and provides a global forum for the nurturing and development of future generations of oncology scientists. Cancer Treatment and Research Communications publishes comprehensive reviews and original studies describing various aspects of basic through clinical research of all tumor types. The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Our mission is to be the premier source of relevant information through promoting excellence in research and facilitating the timely translation of that science to health care and clinical practice.