雅罗斯拉夫尔奶牛不同年龄MSS51和KAT6B基因两种错义突变与体重的关系

IF 0.9 Q3 AGRICULTURE, MULTIDISCIPLINARY
A V Igoshin, N S Yudin, D M Larkin
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引用次数: 0

摘要

雅罗斯拉夫尔牛是19世纪从北方大俄罗斯牛发展而来的俄罗斯本土奶牛品种,它适应了恶劣的气候和恶劣的饲料条件。先前的研究发现,MSS51 (Ala415Glu)和KAT6B (Val105Met)基因中的两个品种特异性错义突变会对动物的体重产生负面影响。本研究旨在通过扩大样本集,确认MSS51和KAT6B基因中的这些错义突变,以及包含这两种突变的突变单倍型与雅罗斯拉夫尔品种不同年龄的活重之间的关联。我们对113头奶牛进行了这些错义变异的基因分型,并分析了它们与出生时、6个月、10个月、12个月、15个月和18个月时的活重的关系,其中包括早期的数据。采用线性回归和单因素方差分析进行统计分析。线性回归结果显示,KAT6B基因突变与6、12和18个月时的活重有显著相关性。MSS51基因突变与6、12、15和18个月的活体重有关。值得注意的是,突变单倍型与6至18个月的所有年龄段的活重有关。单因素方差分析显示,仅在6个月时,活重与KAT6B基因型有显著相关性。对于MSS51基因突变和突变单倍型,在6、12、15和18个月时发现显著相关。在这两项统计测试中,最显著的关联被观察到突变的单倍型,而不是单个变异。这些发现可能有助于提高雅罗斯拉夫尔牛品种杂交牛肉的活重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of two missense mutations in the MSS51 and KAT6B genes with body weight at different ages in cows of the Yaroslavl breed.

The Yaroslavl cattle is a native Russian dairy breed developed in the 19th century from the Northern Great Russian cattle, which were adapted to withstand harsh climates and poor forage conditions. Previous studies identified two breed-specific missense mutations in the MSS51 (Ala415Glu) and KAT6B (Val105Met) genes that negatively impact the body weight of the animals. This study aimed to confirm the association of these missense mutations in the MSS51 and KAT6B genes, along with the mutant haplotype containing both mutations, with live weight at various ages in the Yaroslavl breed using an expanded sample set. We genotyped 113 cows for these missense variants and analyzed their associations with live weight at birth, as well as at 6, 10, 12, 15, and 18 months in a combined sample of 143 animals, which includes earlier data. We employed linear regression and one-way ANOVA for statistical analysis. The results from linear regression indicated significant associations with live weight at 6, 12, and 18 months for the mutation in the KAT6B gene. The MSS51 gene mutation was associated with live weight at 6, 12, 15, and 18 months. Notably, the mutant haplotype was linked to live weight across all ages from 6 to 18 months. One-way ANOVA revealed significant associations of live weight with KAT6B genotypes only at 6 months. For the MSS51 gene mutation and the mutant haplotype, significant associations were found at 6, 12, 15, and 18 months. In both statistical tests, the most significant association was observed for the mutant haplotype rather than for the individual variants. These findings could be instrumental in enhancing the live weight of beef hybrids utilising the Yaroslavl cattle breed.

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来源期刊
Vavilovskii Zhurnal Genetiki i Selektsii
Vavilovskii Zhurnal Genetiki i Selektsii AGRICULTURE, MULTIDISCIPLINARY-
CiteScore
1.90
自引率
0.00%
发文量
119
审稿时长
8 weeks
期刊介绍: The "Vavilov Journal of genetics and breeding" publishes original research and review articles in all key areas of modern plant, animal and human genetics, genomics, bioinformatics and biotechnology. One of the main objectives of the journal is integration of theoretical and applied research in the field of genetics. Special attention is paid to the most topical areas in modern genetics dealing with global concerns such as food security and human health.
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