成人延迟折扣的遗传倾向和受教育程度与青春期前的延迟折扣有关:来自青少年大脑认知发展研究的发现

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES
Jill A. Rabinowitz, Nathaniel Thomas, Justin C. Strickland, John J. Meredith, I-Tzu Hung, Renata B. Cupertino, Julia W. Felton, Brett Gelino, Bryant Stone, Brion S. Maher, Danielle Dick, Richard Yi, Victor Flores-Ocampo, Luis M. García-Marín, Miguel E. Rentería, Abraham A. Palmer, Sandra Sanchez-Roige
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引用次数: 0

摘要

较高的延迟折扣(DD)(即倾向于贬低较大的、延迟的奖励,而不是即时的、较小的奖励)是支持多种健康行为的跨诊断标记。虽然遗传影响在成人中解释了DD的一些变异性,但对青春期前DD的遗传因素知之甚少。我们研究了DD的多基因评分(PGS)、受教育程度和行为特征(即冲动、抑制和外化行为)是否与青春期前的DD表型相关。参与者包括来自青少年大脑认知发展研究的青少年(N = 8982, 53%男性),他们在1年的随访中完成了调整延迟折扣任务,并具有有效的遗传数据。DD、受教育程度、冲动、抑制和外化行为的PGS是基于最大的GWAS创建的。单独的线性混合效应模型在与欧洲人(EUR;n = 4972),非洲(AFR;n = 1769)和Admixed American (AMR;N = 2241)参考面板。在调整了年龄、性别、收入和前十大遗传祖先主成分后,在基因上与EUR参考小组最相似的参与者中,DD的PGS越高,受教育程度越低(但不包括冲动、抑制或外化),DD的发生率越高(即,偏好更快、更小的奖励)。研究结果揭示了发育障碍的遗传倾向和受教育程度对青春期前青少年(尤其是那些基因与欧洲参考样本最相似的人)的折扣倾向的影响,从而促进了我们对这一人群中选择行为的病因学的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Genetic Propensity for Delay Discounting and Educational Attainment in Adults Are Associated With Delay Discounting in Preadolescents: Findings From the Adolescent Brain Cognitive Development Study

Genetic Propensity for Delay Discounting and Educational Attainment in Adults Are Associated With Delay Discounting in Preadolescents: Findings From the Adolescent Brain Cognitive Development Study

Higher delay discounting (DD) (i.e., propensity to devalue larger, delayed rewards over immediate, smaller rewards) is a transdiagnostic marker underpinning multiple health behaviors. Although genetic influences account for some of the variability in DD among adults, less is known about the genetic contributors to DD among preadolescents. We examined whether polygenic scores (PGS) for DD, educational attainment, and behavioral traits (i.e., impulsivity, inhibition, and externalizing behavior) were associated with phenotypic DD among preadolescents. Participants included youth (N = 8982, 53% male) from the Adolescent Brain Cognitive Development Study who completed an Adjusting Delay Discounting Task at the 1-year follow-up and had valid genetic data. PGS for DD, educational attainment, impulsivity, inhibition, and externalizing behaviors were created based on the largest GWAS available. Separate linear mixed effects models were conducted in individuals most genetically similar to European (EUR; n = 4972), African (AFR; n = 1769), and Admixed American (AMR; n = 2241) reference panels. After adjusting for age, sex, income, and the top ten genetic ancestry principal components, greater PGS for DD and lower educational attainment (but not impulsivity, inhibition, or externalizing) were associated with higher rates of DD (i.e., preference for sooner, smaller rewards) in participants most genetically similar to EUR reference panels. Findings provide insight into the influence of genetic propensity for DD and educational attainment on the discounting tendencies of preadolescents, particularly those most genetically similar to European reference samples, thereby advancing our understanding of the etiology of choice behaviors in this population.

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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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