Jose Net, Antoine Hamedi-Sangsari, Taylor Schwartz, Mirelys Barrios, Nicole Brofman, Cedric Pluguez-Turull, Jamie Spoont, Sarah Stamler, Monica Yepes
{"title":"立体定向活检从全视野数字化乳房摄影+数字化乳房断层合成到全视野合成乳房摄影+数字化乳房断层合成后适应症和结果的变化。","authors":"Jose Net, Antoine Hamedi-Sangsari, Taylor Schwartz, Mirelys Barrios, Nicole Brofman, Cedric Pluguez-Turull, Jamie Spoont, Sarah Stamler, Monica Yepes","doi":"10.3390/medsci13010029","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Synthetic 2D mammography was developed to decrease radiation exposure, but to our knowledge there have been no studies evaluating the impact of implementation of full field synthetic mammography/digital breast tomosynthesis (FFSM/DBT) on indications for stereotactic biopsy.</p><p><strong>Objective: </strong>To compare indications and biopsy outcomes for stereotactic biopsy for full field digital mammography (FFDM/DBT) to those of FFSM/DBT.</p><p><strong>Methods: </strong>Retrospective chart review of stereotactic biopsies performed from July 2014 to September 2018. Reports were reviewed and indication for biopsy, lesion size, and final pathology were recorded. Comparison between the two groups following transition to FFSM/DBT in 2016 was performed.</p><p><strong>Results: </strong>66 of 361 stereotactic biopsies performed in the FFDM/DBT group were malignant (PPV 18.3%), compared to 60 of the 391 biopsies performed in the FFSM/DBT group (PPV 15.4%) with no significant difference in PPV (<i>p</i> = 0.281). There were statistically significant changes in indications for biopsies after transitioning to FFSM/DBT: with a decrease in calcifications referred for biopsy (68.03% vs. 89.75%; <i>p</i> < 0.001), and a statistically significant increase in referral of masses (10.74% vs. 4.43%; <i>p</i> < 0.001), asymmetries (15.60% vs. 5.26%; <i>p</i> < 0.001), and architectural distortion (5.63% vs. 0.55%; <i>p</i> < 0.001). PPV across all indications (21.8% in FFSM/DBT vs. 20.3% in FFDM; <i>p</i> = 0.213), and invasive cancer yield (5.63% vs. 3.32%; <i>p</i> = 0.129) remained comparable following transition to FFSM/DBT without statistically significant differences.</p><p><strong>Conclusions: </strong>Following transition to FFSM/DBT, statistically significant shifts in indications for biopsies were observed with a decrease in referral of calcifications and an increase for masses, asymmetries and architectural distortions. PPV for stereotactic biopsy was not significantly different and cancer yield across all indications remained similar, with an increase in invasive cancer diagnosis.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"13 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944155/pdf/","citationCount":"0","resultStr":"{\"title\":\"Change in Indications and Outcomes for Stereotactic Biopsy Following Transition from Full Field Digital Mammography + Digital Breast Tomosynthesis to Full Field Synthetic Mammography + Digital Breast Tomosynthesis.\",\"authors\":\"Jose Net, Antoine Hamedi-Sangsari, Taylor Schwartz, Mirelys Barrios, Nicole Brofman, Cedric Pluguez-Turull, Jamie Spoont, Sarah Stamler, Monica Yepes\",\"doi\":\"10.3390/medsci13010029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Synthetic 2D mammography was developed to decrease radiation exposure, but to our knowledge there have been no studies evaluating the impact of implementation of full field synthetic mammography/digital breast tomosynthesis (FFSM/DBT) on indications for stereotactic biopsy.</p><p><strong>Objective: </strong>To compare indications and biopsy outcomes for stereotactic biopsy for full field digital mammography (FFDM/DBT) to those of FFSM/DBT.</p><p><strong>Methods: </strong>Retrospective chart review of stereotactic biopsies performed from July 2014 to September 2018. Reports were reviewed and indication for biopsy, lesion size, and final pathology were recorded. Comparison between the two groups following transition to FFSM/DBT in 2016 was performed.</p><p><strong>Results: </strong>66 of 361 stereotactic biopsies performed in the FFDM/DBT group were malignant (PPV 18.3%), compared to 60 of the 391 biopsies performed in the FFSM/DBT group (PPV 15.4%) with no significant difference in PPV (<i>p</i> = 0.281). There were statistically significant changes in indications for biopsies after transitioning to FFSM/DBT: with a decrease in calcifications referred for biopsy (68.03% vs. 89.75%; <i>p</i> < 0.001), and a statistically significant increase in referral of masses (10.74% vs. 4.43%; <i>p</i> < 0.001), asymmetries (15.60% vs. 5.26%; <i>p</i> < 0.001), and architectural distortion (5.63% vs. 0.55%; <i>p</i> < 0.001). PPV across all indications (21.8% in FFSM/DBT vs. 20.3% in FFDM; <i>p</i> = 0.213), and invasive cancer yield (5.63% vs. 3.32%; <i>p</i> = 0.129) remained comparable following transition to FFSM/DBT without statistically significant differences.</p><p><strong>Conclusions: </strong>Following transition to FFSM/DBT, statistically significant shifts in indications for biopsies were observed with a decrease in referral of calcifications and an increase for masses, asymmetries and architectural distortions. PPV for stereotactic biopsy was not significantly different and cancer yield across all indications remained similar, with an increase in invasive cancer diagnosis.</p>\",\"PeriodicalId\":74152,\"journal\":{\"name\":\"Medical sciences (Basel, Switzerland)\",\"volume\":\"13 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944155/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical sciences (Basel, Switzerland)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/medsci13010029\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical sciences (Basel, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/medsci13010029","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景：合成二维乳房x线摄影是为了减少辐射暴露而开发的，但据我们所知，还没有研究评估全视野合成乳房x线摄影/数字乳房断层合成（FFSM/DBT）对立体定向活检指征的影响。目的：比较FFDM/DBT与FFSM/DBT立体定向活检的适应证和活检结果。方法：回顾性回顾2014年7月至2018年9月行立体定向活检的图表。回顾报告，并记录活检，病变大小和最终病理的指征。比较两组在2016年过渡到FFSM/DBT后的情况。结果：FFDM/DBT组361例立体定向活检中有66例为恶性（PPV为18.3%），而FFSM/DBT组391例活检中有60例为恶性（PPV为15.4%），PPV无显著差异（p = 0.281）。过渡到FFSM/DBT后，活检适应症有统计学意义的变化：钙化活检减少(68.03% vs 89.75%；P < 0.001)，肿块转诊增加有统计学意义(10.74% vs. 4.43%；P < 0.001)，不对称(15.60% vs. 5.26%；P < 0.001)，建筑变形(5.63% vs. 0.55%；P < 0.001)。所有适应症的PPV (FFSM/DBT组21.8% vs. FFDM组20.3%；P = 0.213)，浸润性癌发生率(5.63% vs. 3.32%；p = 0.129)在过渡到FFSM/DBT后仍然具有可比性，但无统计学显著差异。结论：在过渡到FFSM/DBT后，观察到活检指征的统计学显著变化，钙化的转诊减少，肿块、不对称和结构扭曲的转诊增加。立体定向活检的PPV没有显著差异，所有适应症的癌症发生率保持相似，浸润性癌症诊断增加。
Change in Indications and Outcomes for Stereotactic Biopsy Following Transition from Full Field Digital Mammography + Digital Breast Tomosynthesis to Full Field Synthetic Mammography + Digital Breast Tomosynthesis.
Background: Synthetic 2D mammography was developed to decrease radiation exposure, but to our knowledge there have been no studies evaluating the impact of implementation of full field synthetic mammography/digital breast tomosynthesis (FFSM/DBT) on indications for stereotactic biopsy.
Objective: To compare indications and biopsy outcomes for stereotactic biopsy for full field digital mammography (FFDM/DBT) to those of FFSM/DBT.
Methods: Retrospective chart review of stereotactic biopsies performed from July 2014 to September 2018. Reports were reviewed and indication for biopsy, lesion size, and final pathology were recorded. Comparison between the two groups following transition to FFSM/DBT in 2016 was performed.
Results: 66 of 361 stereotactic biopsies performed in the FFDM/DBT group were malignant (PPV 18.3%), compared to 60 of the 391 biopsies performed in the FFSM/DBT group (PPV 15.4%) with no significant difference in PPV (p = 0.281). There were statistically significant changes in indications for biopsies after transitioning to FFSM/DBT: with a decrease in calcifications referred for biopsy (68.03% vs. 89.75%; p < 0.001), and a statistically significant increase in referral of masses (10.74% vs. 4.43%; p < 0.001), asymmetries (15.60% vs. 5.26%; p < 0.001), and architectural distortion (5.63% vs. 0.55%; p < 0.001). PPV across all indications (21.8% in FFSM/DBT vs. 20.3% in FFDM; p = 0.213), and invasive cancer yield (5.63% vs. 3.32%; p = 0.129) remained comparable following transition to FFSM/DBT without statistically significant differences.
Conclusions: Following transition to FFSM/DBT, statistically significant shifts in indications for biopsies were observed with a decrease in referral of calcifications and an increase for masses, asymmetries and architectural distortions. PPV for stereotactic biopsy was not significantly different and cancer yield across all indications remained similar, with an increase in invasive cancer diagnosis.
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