营养状况与癌症免疫治疗的PFS和OS: MOUSEION-010荟萃分析

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2025-03-01 Epub Date: 2025-03-25 DOI:10.1080/1750743X.2025.2483656

Elsa Vitale, Lorenza Maistrello, Alessandro Rizzo, Oronzo Brunetti, Raffaella Massafra, Veronica Mollica, Francesco Massari, Matteo Santoni

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引用次数: 0

摘要

背景：MOUSEION-010荟萃分析评估了接受免疫检查点抑制剂（ICIs）治疗的癌症患者的营养状况与临床结果（如无进展生存期（PFS）和总生存期（OS））之间的关系。方法：采用预后营养指数（PNI）、老年营养风险指数（GNRI）和控制营养状况（CONUT）指标评价营养状况。参考的数据库有：Embase、PubMed、Scopus和Web of Science。结果：PNI和GNRI指数与PFS和OS均无显著相关性，而CONUT指数与两组PFS有显著性差异，有利于对照组(Z = 4.04；p = 0.10])。OS也有同样的趋势(Z = 4.24；P P = 0.028])，研究的数量并没有显示出足够的统计能力来获得可靠的结果。结论：营养不良对癌症患者有负面影响，尤其是晚期癌症患者。我们的研究结果可能与身体能力和日常活动表现的降低、治疗方案的依从性降低以及生存期缩短有关。

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Nutritional conditions and PFS and OS in cancer immunotherapy: the MOUSEION-010 meta-analysis.

Background: The MOUSEION-010 Meta-Analysis assessed the association between nutritional status and clinical outcomes such as Progression Free Survival (PFS) and Overall Survival (OS) among cancer patients treated with immune checkpoint inhibitors (ICIs).

Methods: Nutritional status was assessed based on the Prognostic Nutrition Index (PNI), Geriatric Nutritional Risk Index (GNRI) and Controlling Nutritional Status (CONUT) indexes. Databases consulted were: Embase, PubMed, Scopus and Web of Science.

Results: PNI and GNRI indexes did not show a significant association with both PFS and OS, while CONUT index displayed a significant difference in PFS between the two groups, in favor of the control group (Z = 4.04; p < 0.01) also without any publication bias (β= -1.27; 95% CI = [-2.13; -0.42]; p = 0.10]). The same trend was recorded in OS, too (Z = 4.24; p < 0.01). However, publication bias was present (β = 1.89; 95% CI = [1.26; 2.54]; p = 0.028]) and the numerosity of the studies did not reveal the sufficient statistical power to obtain reliable results.

Conclusion: Malnutrition could negatively impact cancer patients, especially in advanced phases. Our findings could be associated with the reduction of physical ability and daily activity performance, lower compliance with treatment protocols, and shorter survival outcomes.

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.