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IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Digestion Pub Date : 2025-03-25 DOI:10.1159/000545457

Yasushi Adachi, Masanori Nojima, Yingsong Lin, Yasushi Sasaki, Hiro-O Yamano, Hiroshi Nakase, Kenji Wakai, Mitsuru Mori, Akiko Tamakoshi

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引用次数: 0

摘要

导言：有丝分裂原胰岛素样生长因子（IGF）的活性受 IGF 结合蛋白（IGFBP）控制。结直肠癌（CRC）具有异质性，左侧和右侧结直肠癌显示出不同的临床和分子特征。这项病例对照研究嵌套在日本协作队列研究中，按部位评估了血清中 IGF 相关分子水平与 CRC 发病率之间的关系。方法：基线调查获得了 39,242 名参与者的血清样本。随访期间确诊为 CRC 的受试者被视为病例。采用条件逻辑回归模型计算与 IGF 相关分子有关的癌症发病率的几率比 (OR)。结果：该分析包括 176 例病例和 524 例对照。没有发现任何 IGF 相关分子与总体或左侧 CRC 风险相关。总 IGFBP3 和游离 IGFBP3（估算为 IGFBP3-（IGF1+IGF2））均与右侧 CRC 的发病率相关（趋势比分别为 0.027 和 0.003），其中总 IGFBP3 和游离 IGFBP3 的第三三分位数风险最高（OR 分别为 6.25 和 7.96）。游离 IGF 的估计值为（IGF1+IGF2）/IGFBP3，它与右侧 CRC 的发病率成反比（P-for-trends=0.014），其中第三分位数的风险最低（OR=0.18）。在随访3年以上的受试者中，IGF相关分子与总体CRC的关系相似。游离 IGFBP3 与右侧 CRC 的发病率相关（P-趋势=0.004）。游离 IGF 与右侧 CRC 的发病率成反比（趋势比=0.002）。然而，游离 IGF 与左侧 CRC 的发病风险相关（趋势比=0.041），其中第三三分位数的风险最高（OR=3.10）。结论：血清 IGF 相关分子与 CRC 风险相关。这些关联可能因肿瘤位置而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Associations between serum insulin-like growth factor-related molecules and colorectal cancer risk by tumor location: a nested case-control study.

Introduction, The activity of the mitogen insulin-like growth factor (IGF) is controlled by IGF-binding protein (IGFBP). Colorectal cancers (CRCs) are heterogeneous, with left- and right-sided CRC showing different clinical and molecular characteristics. This case-control study, nested in the Japan Collaborative Cohort study, assessed associations between serum levels of IGF-related molecules and incidences of CRC by location. Methods, A baseline survey obtained serum samples from 39,242 participants. Subjects diagnosed with CRC during follow-up were regarded as cases. Conditional logistic regression modeling was used to calculate odds ratios (ORs) for cancer incidence associated with IGF-related molecules. Results, This analysis included 176 cases and 524 controls. No IGF-related molecules appeared associated with risks of overall or left-sided CRC. Both total IGFBP3 and free IGFBP3 (estimated as IGFBP3-(IGF1+IGF2)) were associated with incidence of right-sided CRC (P-for-trends=0.027 and 0.003, respectively), with the third tertile of total and free IGFBP3 showing the highest risk (OR=6.25 and 7.96, respectively). Free IGF, estimated as (IGF1+IGF2)/IGFBP3, was inversely associated with incidence of right-sided CRC (P-for-trends=0.014), with the third tertile showing the lowest risk (OR=0.18). Among subjects followed for over 3 years, association of IGF-related molecules with overall CRC was similar. Free IGFBP3 was associated with incidence of right-sided CRC (P-for-trends=0.004). Free IGF was inversely associated with incidence of right-sided CRC (P-for-trends=0.002). However, free IGFs were associated with risk of left-sided CRC (P-for-trends=0.041), with the third tertile showing the highest risk (OR=3.10). Conclusions, Serum IGF-related molecules are associated with risk of CRC. These associations might differ by tumor location.

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来源期刊

Digestion 医学-胃肠肝病学

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Digestion'' concentrates on clinical research reports: in addition to editorials and reviews, the journal features sections on Stomach/Esophagus, Bowel, Neuro-Gastroenterology, Liver/Bile, Pancreas, Metabolism/Nutrition and Gastrointestinal Oncology. Papers cover physiology in humans, metabolic studies and clinical work on the etiology, diagnosis, and therapy of human diseases. It is thus especially cut out for gastroenterologists employed in hospitals and outpatient units. Moreover, the journal''s coverage of studies on the metabolism and effects of therapeutic drugs carries considerable value for clinicians and investigators beyond the immediate field of gastroenterology.