Morten Yung Isaksen, Olav Karsten Vintermyr, Håkon Reikvam
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引用次数: 0
摘要
淋巴浆细胞性淋巴瘤（LPL）通常伴有血清单克隆免疫球蛋白M（IgM）。然而，在某些情况下，这些细胞也会分泌 IgA 或 IgG 单克隆蛋白，或保持非分泌状态。我们报告了一例分泌 LPL IgG 的患者，该患者在病程中出现贫血和脾脏肿大，需要使用硼替佐米、地塞米松和利妥昔单抗进行治疗。该病例说明，临床医生和病理学家需要将LPLs作为一种鉴别诊断，即使没有血清单克隆IgM：作者已确认本论文无需进行临床试验注册。
MYD88-mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case Report
Lymphoplasmacytic lymphomas (LPL) are usually associated with serum monoclonal immunoglobulin M (IgM). Nevertheless, in some cases, these cells may secrete IgA or IgG monoclonal proteins or remain non-secretory. We report a case from a patient with LPL-secreting IgG who developed anaemia and splenomegaly during the disease course that necessitated treatment with bortezomib, dexamethasone, and rituximab. The case illustrates the need for clinicians and pathologists to consider LPLs as a differential diagnosis also without a serum monoclonal IgM.
Clinical Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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