基于指南治疗的Graves病患者的极限环分析

Q3 Engineering

IFAC-PapersOnLine Pub Date : 2025-01-01 DOI:10.1016/j.ifacol.2025.03.043

Thomas Benninger , Martin Horn , Markus Reichhartinger

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引用次数: 0

摘要

简要回顾现有的格雷夫斯病用药剂量指南。这促使我们通过极限环稳定性分析推导出推荐策略和性能评估。为此，将现有的数学治疗模型简化，纳入医学方面。从应用的角度来看，这与次优治疗有关，次优治疗可以通过比例控制器与闭环模型的时间离散化相结合来近似，以纳入与医生定期预约的影响。提出的结果强调了治疗过程中需要考虑的关键方面。

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Limit Cycle Analysis of Guideline-based treated Graves’ Disease Patients

A brief review of existing medical dosage guidelines for Graves’ disease is conducted. This motivates to derive a recommendation strategy and a performance assessment via limit cycle stability analysis. For this purpose, an existing mathematical treatment model is simplified by incorporating medical aspects. From an application point of view, this is related to suboptimal treatments which can be approximated by a proportional controller in combination with a time-discretization of the closed-loop model for incorporating the effect of regular appointments with a physician. The presented results highlight critical aspects to be considered during treatment.

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来源期刊

IFAC-PapersOnLine Engineering-Control and Systems Engineering

CiteScore

1.70

自引率

0.00%

发文量

1122

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