Martin Tobi, Harvinder Talwar, Noreen F Rossi, Warren Lockette, Benita McVicker
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A Practical Format to Organize Cancer Constellations Using Innate Immune System Biomarkers: Implications for Early Diagnosis and Prognostication.
Cancer discovery is directed at the identification of a specific cancer type which allows for specific therapeutic interventions.
Background/objectives: Recently, similar immune checkpoint therapeutics have been applied with success across several cancer types, opening the field for other immune disruptive interventions that have practical applications.
Methods: We have discovered an innate immune system (InImS) biomarker that allows for the characterization of allied cancer subtypes and outliers that might aid with diagnosis, treatment, and prognostication.
Results: These InImS biomarkers are related to PD-L1 treatment outcomes and can be potentially manipulated by dietary means.
Conclusions: The FERAD (ferritin-fecal p87) and absolute neutrophil/lymphocyte (aNLR) ratios are two such InImS biomarkers and we show herein, that they allow for the discovery of diagnosis and prognostication patterns, as demonstrated by this study.
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