Daxx和HIRA病毒化-染色质重塑复合体如何影响DNA病毒感染。

IF 4.7 Q1 VIROLOGY
Julia Mai , Masih Nazari , Thomas Stamminger , Sabrina Schreiner
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引用次数: 0

摘要

Daxx和HIRA是宿主对DNA病毒感染反应的关键蛋白。Daxx参与细胞凋亡、转录调控和应激反应。在DNA病毒感染期间,Daxx帮助调节免疫反应和病毒进展。腺病毒和疱疹病毒等病毒可以利用Daxx来逃避免疫检测,要么以其降解为目标,要么抑制其功能。Daxx还与染色质相互作用以调节转录,病毒可以操纵转录以增强自身基因的表达和复制。HIRA是一种组蛋白伴侣,据报道对染色质组装和基因调控至关重要。它在维持染色质结构和调节基因可及性方面起着关键作用。在DNA病毒感染过程中,HIRA影响染色质重塑,影响病毒和宿主DNA的可及性,从而影响病毒复制和基因表达。此外,组蛋白变体H3.3对于维持活性染色质状态至关重要。它独立于DNA复制并入染色质,并与活性基因区域相关。在病毒感染过程中,H3.3动力学可以改变,影响病毒基因组的可及性和复制效率。总的来说,Daxx和HIRA是协调病毒感染程序、维持潜伏期和/或持久性以及通过调节染色质动力学和宿主免疫反应影响病毒诱导转化的组成部分,一旦完全了解,它们就成为治疗策略的重要靶点。本文综述了各种DNA病毒及其与Daxx和HIRA的串扰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Daxx and HIRA go viral – How chromatin remodeling complexes affect DNA virus infection
Daxx and HIRA are key proteins in the host response to DNA virus infections. Daxx is involved in apoptosis, transcription regulation, and stress responses. During DNA virus infections, Daxx helps modulate the immune response and viral progression. Viruses like adenoviruses and herpesviruses can exploit Daxx to evade immune detection, either by targeting it for degradation or inhibiting its function. Daxx also interacts with chromatin to regulate transcription, which viruses can manipulate to enhance their own gene expression and replication. HIRA is a histone chaperone and reported to be essential for chromatin assembly and gene regulation. It plays a critical role in maintaining chromatin structure and modulating gene accessibility. During DNA virus infection, HIRA influences chromatin remodeling, affecting both viral and host DNA accessibility, which impacts viral replication and gene expression. Additionally, the histone variant H3.3 is crucial for maintaining active chromatin states. It is incorporated into chromatin independently of DNA replication and is associated with active gene regions. During viral infections, H3.3 dynamics can be altered, affecting viral genome accessibility and replication efficiency. Overall, Daxx and HIRA are integral to orchestrating viral infection programs, maintaining latency and/or persistence, and influencing virus-induced transformation by modulating chromatin dynamics and host immune responses, making them significant targets for therapeutic strategies once fully understood. Here, we summarize various DNA viruses and their crosstalk with Daxx and HIRA.
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来源期刊
Tumour Virus Research
Tumour Virus Research Medicine-Infectious Diseases
CiteScore
6.50
自引率
2.30%
发文量
16
审稿时长
56 days
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