炎症对前列腺肿瘤动态的影响:前列腺癌和良性前列腺增生的病理学观点。

IF 1.3 Q3 UROLOGY & NEPHROLOGY
Archivio Italiano di Urologia e Andrologia Pub Date : 2025-03-28 Epub Date: 2025-03-24 DOI:10.4081/aiua.2025.13353
Syakri Syahrir, Muhammad Asykar Palinrungi, Mochammad Hatta, Khoirul Kholis, Syarif Syarif, Abdul Azis, Muhammad Faruk
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引用次数: 0

摘要

慢性炎症与前列腺癌(PCa)和良性前列腺增生(BPH)的发病机制有关。本研究评估了炎症标志物成纤维细胞生长因子-2 (FGF2)、白细胞介素(IL)-8和IL-6在PCa和BPH组织中的相关性,以了解它们在疾病进展中的作用。方法:对62例诊断为前列腺癌或前列腺增生的男性患者的前列腺标本进行横断面调查。经尿道前列腺切除术(TURP)取标本,苏木精和伊红染色,观察炎症浸润和侵袭性。ELISA法检测FGF2、IL-8、IL-6水平。统计分析采用卡方检验和逻辑回归检验。结果:所有BPH病例均有高度炎症反应(100%),而PCa病例无高度炎症反应。在BPH组织中,IL-8和IL-6水平升高与高度炎症有显著相关性(p < 0.05)。另一方面,前列腺癌组织中FGF2水平明显高于良性组织(p < 0.05)。前列腺癌组织中FGF2水平升高和缺乏高级别炎症表明前列腺癌和BPH的不同致病过程。结论:本研究强调慢性炎症在BPH发展中的重要性,其中IL-8和IL-6起重要作用。结果表明,通过关注IL-8和IL-6来治疗BPH可能是有益的。前列腺癌组织中FGF2水平升高表明该蛋白可作为前列腺癌的生物标志物和治疗靶点。这些发现强调了针对炎症和生长因子途径治疗前列腺疾病的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The impact of inflammation on prostate tumor dynamics: a pathological perspective on prostate cancer and benign prostatic hyperplasia.

Introduction: Chronic inflammation is associated to the pathogenesis of prostate cancer (PCa) and benign prostatic hyperplasia (BPH). This study evaluated the correlation between inflammatory markers fibroblast growth factor-2 (FGF2), interleukin (IL)-8, and IL-6 in PCa and BPH tissues to understand their involvement in disease progression.

Methods: A cross-sectional investigation was carried out, examining prostate specimens from 62 male patients diagnosed with PCA or BPH. Specimens were taken via transurethral resection of the prostate (TURP) and stained with hematoxylin and eosin to look for inflammatory infiltrates and aggressiveness. The levels of FGF2, IL-8, and IL-6 were evaluated using ELISA. Chi-square and logistic regression tests were used in the statistical analysis.

Results: High-grade inflammation was found in all BPH cases (100%), but not in PCa cases. In BPH tissues, elevated levels of IL-8 and IL-6 had a significant correlation with high-grade inflammation (p < 0.05). On the other hand, PCa tissues had considerably greater FGF2 levels than benign tissues (p < 0.05). Elevated FGF2 levels and the lack of high-grade inflammation in PCa tissues point to different pathogenic processes in PCa and BPH.

Conclusions: This study emphasizes the importance of chronic inflammation in BPH development, with IL-8 and IL-6 playing essential roles. The results imply that treating BPH by focusing on IL-8 and IL-6 may be beneficial. Increased levels of FGF2 in PCa tissues suggest that this protein may be used as a biomarker and therapeutic target for PCa. These findings highlight the importance of targeting both inflammatory and growth factor pathways for treating prostatic disorders.

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来源期刊
CiteScore
2.10
自引率
35.70%
发文量
72
审稿时长
10 weeks
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