Eun Joo Baek, Sun Mee Shin, Seong Jun Kim, Kwang Ho Kim, Kwang Joong Kim, Eun Joo Park
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Alitretinoin for the Treatment of Lichen Amyloidosis: A Retrospective, Observational Study and an In Vitro Study
Background: Lichen amyloidosis (LA) is the most common form of localized cutaneous amyloidosis, often accompanied by severe pruritus. Treatment options are limited, and alitretinoin, a systemic retinoid, has shown promise in managing refractory cases.
Objective: This study aimed to evaluate the efficacy of alitretinoin in treating LA and its effects on keratinocytes.
Methods: We conducted a retrospective analysis of 13 patients diagnosed with LA treated with alitretinoin. In addition, an in vitro study assessed the impact of alitretinoin on keratinocyte inflammation markers.
Results: Of the 13 patients, 4 (30.77%) achieved complete clearance of lesions, demonstrating excellent improvement. The remaining 9 (69.23%) showed substantial improvement, with almost clear or mild residual lesions. In vitro, alitretinoin significantly decreased levels of IL-33, periostin, CCL5, and PTGES.
Conclusion: Alitretinoin demonstrated effectiveness in treating LA, with favorable outcomes in both clinical and in vitro settings. These findings support alitretinoin as a viable treatment option for LA.
期刊介绍：
Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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