耳蜗机械刺激治疗听力损失：主动耳蜗模型正向刺激与反向刺激的比较

IF 4.9 2区医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer methods and programs in biomedicine Pub Date : 2025-03-14 DOI:10.1016/j.cmpb.2025.108721

Zhaohai Liu , Houguang Liu , Weiwei Guo , Wei Chen , Wen Liu , Shanguo Yang

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引用次数: 0

摘要

背景与目的宇宙刺激是一种针对中度传导性听力损失和混合性听力损失的有源中耳植入物的刺激方式。然而，先前的研究通过被动耳蜗模型研究了反向刺激，模拟了深度感音神经性听力损失，这超出了AMEI的适应症。因此，我们研究了不同听力损失下耳蜗对反向刺激的反应，并将其与正向刺激的反应进行了比较。方法人耳模型由人耳宏观动力学模型、耳蜗微观动力学模型和耳蜗电路模型组成。将人耳组织简化为刚度、阻尼和质量，建立了人耳宏观动力学模型和耳蜗微观动力学模型。通过耦合耳蜗电路模型实现了耳蜗有源放大。在此基础上，计算了耳蜗对正向和反向刺激的反应。结果结果表明，逆行刺激时耳蜗反应明显高于正向刺激，且随着刺激强度的增大，耳蜗反应差异先减小后增大。传导性听力损失显著降低耳蜗对正向刺激的反应，但对反向刺激的影响较小。外毛细胞听力损失显著降低耳蜗对正向和反向刺激的反应，但随着刺激幅度的增加，这种影响逐渐减弱。结论本研究比较了听力正常和听力损失患者耳蜗对正向和反向刺激的反应差异，有助于圆窗刺激的优化。

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Mechanical stimulation of cochlea for treatment of hearing loss: Comparison between forward stimulation and reverse stimulation with an active cochlear model

Background and objective

Reverse stimulation is a stimulation mode of the active middle-ear implants (AMEIs), targeted at moderate conductive hearing loss and mixed hearing loss. However, previous studies investigated reverse stimulation through passive cochlear models that simulate profound sensorineural hearing loss, which is beyond the AMEI's indications. Therefore, we investigated the cochlear responses to reverse stimulation under different hearing loss and compared them with those to forward stimulation.

Methods

The human ear model consists of a human ear macro dynamic model, a cochlear micro dynamic model, and a cochlear circuit model. The human ear macro dynamic model and cochlear micro dynamic model were developed by simplifying the human ear tissues into stiffness, damping, and mass. The cochlear active amplification was realized by coupling the cochlear circuit model. Based on the model, the cochlear responses to forward and reverse stimulation were calculated.

Results

The results show that the cochlear responses to reverse stimulation are higher than those to forward stimulation, and the difference in cochlear responses decreases and then increases with increasing stimulus magnitude. Conductive hearing loss significantly reduces cochlear response to forward stimulation but has less effect on reverse stimulation. Outer hair cell hearing loss significantly reduces cochlear response to both forward and reverse stimulation, but the effect diminishes to nothing as the stimulation amplitude increases.

Conclusions

This study compared the cochlear responses differences in normal hearing and hearing loss to forward and reverse stimulation, contributing to the optimization of the round window stimulating AMEIs.

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来源期刊

Computer methods and programs in biomedicine 工程技术-工程：生物医学

CiteScore

12.30

自引率

6.60%

发文量

601

审稿时长

135 days

期刊介绍： To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.