角膜共聚焦显微镜作为检测多发性硬化症轴突变性及其严重程度的工具：一项荟萃分析

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2025-03-18 DOI:10.1016/j.msard.2025.106397

Ali Al-Salahat , Alexander Hall , Yu-Ting Chen , Ram Narayan , Evanthia Bernitsas

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引用次数: 0

摘要

背景与目的本研究探讨角膜共聚焦显微镜（CCM）在多发性硬化（pwMS）患者轴突变性检测中的作用及其与严重程度的相关性。方法在PubMed、Scopus和b谷歌Scholar中进行文献检索。角膜神经纤维密度（CNFD）、角膜神经纤维分支密度（CNBD）、角膜神经纤维长度（CNFL）在pwMS和健康对照之间的差异采用风险比（RR）进行量化，由于观察到高度异质性，采用随机效应模型进行估计。采用随机效应meta回归评价严重程度与CNFD、CNFL和CNBD之间的关系。结果351例pwMS共纳入8项研究。与对照组相比，pwMS患者的CNFD和CNFL较低（Hedge's G效应值= -1.53,95% CI:2.62, -0.44, p = 0.01）。meta回归分析显示，CNFD (Mean b = -1.93, 95% CI (-3.32, -0.55), p = 0.01), CNBD (Mean b = -33.36, 95% CI (-48.90, -17.82), p <；.01)和CNFL (Mean b = -2.31, 95% CI (-2.94, -1.68) p <；.01)与多发性硬化严重程度评分（MSSS）有显著相关性，但与扩展残疾严重程度评分（EDSS）无显著相关性。ccm可以作为pwMS轴突变性的非侵入性成像生物标志物。

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Corneal confocal microscopy as a tool for detecting axonal degeneration in multiple sclerosis and correlation with severity: A meta-analysis

Background and Objectives

This study explores the role of corneal confocal microscopy (CCM) in detecting axonal degeneration in people with multiple sclerosis (pwMS) and its correlation with severity.

Methods

A literature search was conducted across PubMed, Scopus and Google Scholar. Differences in corneal nerve fiber density (CNFD), corneal nerve fiber branch density (CNBD), corneal nerve fiber length (CNFL), between pwMS and healthy controls were quantified using risk ratio (RR) and estimated using random effects models due to high observed heterogeneity. Random-effects meta-regression was utilized to evaluate the relationship between severity and CNFD, CNFL and CNBD.

Results

A total of 8 studies were included with 351 pwMS. CNFD and CNFL were lower in pwMS compared to controls (Hedge's G Effect Size = -1.53, 95 % CI:2.62, -0.44, p = .01). Meta-regression analysis showed that CNFD (Mean b = -1.93, 95 % CI (-3.32, -0.55), p = .01), CNBD (Mean b = -33.36, 95 % CI (-48.90, -17.82), p < .01) and CNFL (Mean b = -2.31, 95 % CI (-2.94, -1.68) p < .01) had significant associations with Multiple Sclerosis Severity Score (MSSS) but not with Extended Disability Severity Score (EDSS).

Discussion

CCM can be a non-invasive imaging biomarker for axonal degeneration in pwMS.

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.