山梨糖醇A和山梨糖醇B：两种具有前所未有骨架的山梨糖醇类，通过分子网络策略从海绵来源的真菌青霉菌中发现

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-24 DOI:10.1021/acs.orglett.5c00595

Ze-Bin Chen, Hui-Xian Liang, Wan-Ying Guo, Dai-Chun Li, Xiao-Jian Liao, Guo-Dong Chen, Shi-Hai Xu, Bing-Xin Zhao

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引用次数: 0

摘要

山梨糖醇A(1)及其生物合成前体山梨糖醇B(2)是两种具有前所未有骨架的新型山梨糖醇类化合物，通过分子网络从海绵来源的真菌青霉菌中分离得到。通过光谱分析和量子化学鉴定了它们的结构。他们都展示了一种创新的山梨糖醇和柑桔素衍生物的融合模式。化合物1是具有独特的笼状2,5-二恶五环[10.4.03,11.04,8.04,15]十四烷支架的山梨霉素类化合物的第一个例子。提出了可能的生物发生途径，并对其抗肿瘤和抗真菌活性进行了评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Sorbicitrinols A and B, Two Sorbicillinoids with Unprecedented Skeletons Uncovered from Sponge-Derived Fungus Penicillium sp. S4I4-3 by a Molecular Networking Strategy

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Sorbicitrinols A and B, Two Sorbicillinoids with Unprecedented Skeletons Uncovered from Sponge-Derived Fungus Penicillium sp. S4I4-3 by a Molecular Networking Strategy

Sorbicitrinol A (1) and its biosynthetic precursor sorbicitrinol B (2), two novel sorbicillinoids with unprecedented skeletons, were isolated from the sponge-derived fungus Penicillium sp. by molecular networking. Their structures were identified by spectroscopic analyses and quantum chemistry. Both of them exhibited an innovative fusion pattern of sorbicillinol and a citrinin derivative. Compound 1 was the first example of a sorbicillinoid featuring the unique cage-like 2,5-dioxa-pentacyclo[10.4.0^3,11.0^4,8.0^4,15]tetradecane scaffold. Plausible biogenetic pathways were proposed, and their antitumor and antifungal activities were also evaluated.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.